Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió acceptadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/167742
Recent advances and perspectives in the design and development of polymyxins
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
The rise of bacterial pathogens with acquired resistance to almost all available antibiotics is becoming a serious public health issue. Polymyxins, antibiotics that were mostly abandoned a few decades ago because of toxicity concerns, are ultimately considered as a last-line therapy to treat infections caused by multi-drug resistant Gram-negative bacteria. This review surveys the progress in understanding polymyxin structure, chemistry, mechanisms of antibacterial activity and nephrotoxicity, biomarkers, synergy and combination with other antimicrobial agents and antibiofilm properties. An update of recent efforts in the design and development of a new generation of polymyxin drugs is also discussed. A novel approach considering the modification of the scaffold of polymyxins to integrate metabolism and detoxification issues into the drug design process is a promising new line to potentially prevent accumulation in kidney and reduce nephrotoxicity
Matèries (anglès)
Citació
Citació
RABANAL ANGLADA, Francesc, CAJAL VISA, Yolanda. Recent advances and perspectives in the design and development of polymyxins. _Natural Product Reports_. 2017. Vol. 34, núm. 7, pàgs. 886-908. [consulta: 21 de gener de 2026]. ISSN: 0265-0568. [Disponible a: https://hdl.handle.net/2445/167742]