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rinchai2017_2845.pdf (4.43 MB)

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2017-07-18

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cc by (c)  Rinchai D et al., 2017
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/119074

Blood Interferon Signatures Putatively Link Lack of Protection Conferred by the RTS,S Recombinant Malaria Vaccine to an Antigen-specific IgE Response

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http://dx.doi.org/10.12688/f1000research.7093.2

Abstract

Malaria remains a major cause of mortality and morbidity worldwide. Progress has been made in recent years with the development of vaccines that could pave the way towards protection of hundreds of millions of exposed individuals. Here we used a modular repertoire approach to re-analyze a publically available microarray blood transcriptome dataset monitoring the response to malaria vaccination. We report the seminal identification of interferon signatures in the blood of subjects on days 1, 3 and 14 following administration of the third dose of the RTS,S recombinant malaria vaccine. These signatures at day 1 correlate with protection, and at days 3 and 14 to susceptibility to subsequent challenge of study subjects with live parasites. In addition we putatively link the decreased abundance of interferon-inducible transcripts observed at days 3 and 14 post-vaccination with the elicitation of an antigen-specific IgE response in a subset of vaccine recipients that failed to be protected by the RTS,S vaccine. Furthermore, profiling of antigen-specific levels of IgE in a Mozambican cohort of malaria-exposed children vaccinated with RTS,S identified an association between elevated baseline IgE levels and subsequent development of naturally acquired malaria infection during follow up. Taken together these findings warrant further investigation of the role of antigen-specific IgE in conferring susceptibility to malaria infection.

Subject

Malària, Vacuna de la malària

Subject (English)

Malaria, Malaria vaccine

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Articles publicats en revistes (ISGlobal)

Citation

RINCHAI, Darawan, et al. Blood Interferon Signatures Putatively Link Lack of Protection
                Conferred by the RTS,S Recombinant Malaria Vaccine to an
                Antigen-specific IgE Response. F1000Research. 2017. Vol. 4, pags. 919. ISSN 2046-1402. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/119074

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