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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/119757
Radical Cyclization of Trichloroacetamides: Synthesis of Lactams
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Trichloroacetamides can act as radical precursors to synthesize nitrogen-containing heterocycles in a variety of processes, mainly involving atom transfer radical cyclizations (ATRC), mediated by Cu(I) or Ru(II) catalysts, and the hydride reductive method, employing either Bu3SnH or (Me3Si)3SiH, or recently NaBH3CN. Additionally, amine-mediated single-electron transfer cyclizations, as well as radical processes promoted by Ni, Fe, Mn, Ti, and Ag, have been developed.
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COUSSANES, Guilhem, et al. Radical Cyclization of Trichloroacetamides: Synthesis of Lactams. Synthesis. 2017. Vol. 49, num. 07, pags. 1481-1499. ISSN 0039-7881. [consulted: 15 of June of 2026]. Available at: https://hdl.handle.net/2445/119757