Immunostaining Protocol: P-Stat3 (Xenograft and Mice)

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dc.contributor.authorCalon, Alexandre
dc.contributor.authorEspinet, Elisa
dc.contributor.authorPalomo Ponce, Sergio
dc.contributor.authorTauriello, Daniele V. F.
dc.contributor.authorIglesias, Mar
dc.contributor.authorCespedes, María Virtudes
dc.contributor.authorSevillano, Marta
dc.contributor.authorNadal, Cristina
dc.contributor.authorJung, Peter
dc.contributor.authorZhang, Xiang H. F.
dc.contributor.authorByrom, Daniel
dc.contributor.authorRiera i Escalé, Antoni
dc.contributor.authorRossell, David
dc.contributor.authorMangues, Ramon
dc.contributor.authorMassagué i Solé, Joan, 1953-
dc.contributor.authorSancho, Elena
dc.contributor.authorBatlle, Eduard
dc.date.accessioned2022-02-24T19:00:57Z
dc.date.available2022-02-24T19:00:57Z
dc.date.issued2014-03-05
dc.date.updated2022-02-24T12:05:43Z
dc.description.abstractWe sought to understand the mechanisms behind the potent effect of stromal TGF-beta program on the capacity of colorectal cancer (CRC) cells to initiate metastasis. We discovered that mice subcutaneous tumors and metastases generated in the context of a TGF-beta activated microenvironment displayed prominent accumulation of p-STAT3 in CRC cells compared with those derived from control cells. STAT3 signaling depended on GP130 as shown by strong reduction of epithelial p STAT3 levels upon GP130 shRNA-mediated knockdown in CRC cells.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idimarina6544612
dc.identifier.issn2331-8325
dc.identifier.urihttps://hdl.handle.net/2445/183467
dc.language.isoeng
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.21769/BioProtoc.1120
dc.relation.ispartofBio-protocol, 2014, vol. 4, num. 9, p. e1120
dc.relation.urihttps://doi.org/10.21769/BioProtoc.1120
dc.rights(c) Bio-protocol LLC, 2014
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
dc.subject.classificationCàncer colorectal
dc.subject.classificationMetàstasi
dc.subject.classificationExpressió gènica
dc.subject.otherColorectal cancer
dc.subject.otherMetastasis
dc.subject.otherGene expression
dc.titleImmunostaining Protocol: P-Stat3 (Xenograft and Mice)
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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