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2017-04-11

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/164122

An overview of antimicrobial peptides and the latest advances in their development

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INTRODUCTION: The recent dramatic increase in the incidence of antimicrobial resistance has been recognized by organizations such as the United Nations and World Health Organization as well as the governments of the USA and several European countries. A relatively new weapon in the fight against severe infections caused by multi-drug resistant bacteria is antimicrobial peptides (AMPs). These include colistin, currently regarded as the last line of antimicrobial therapy against multi-drug resistant microorganisms. Areas covered: Here, the authors provide an overview of the current research on AMPs. The focus is AMPs currently being developed for the treatment of recalcitrant bacterial infections, the synergies of AMPs and antibiotics, and the activity of AMPs against biofilm. This review also includes a brief introduction into the use of AMPs in infections caused by Mycobacterium, fungi, and parasites. Expert opinion: In research into new antimicrobials, AMPs are gaining increasing attention. While many are natural and are produced by a wide variety of organisms, others are being newly designed and chemically synthesized in the laboratory to achieve novel antimicrobial agents. The same strategy to fight infections in nature is thus being effectively exploited to safeguard human and animal health.

Recurs relacionat

https://doi.org/10.1080/14712598.2017.1315402

Matèries

Antibiòtics, Pèptids, Resistència als medicaments, Espectrometria de masses

Matèries (anglès)

Antibiotics, Peptides, Drug resistance, Mass spectrometry

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Articles publicats en revistes (Química Inorgànica i Orgànica)

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SIERRA ORTIGOSA, Josep Maria, et al. An overview of antimicrobial peptides and the latest advances in their development. Expert Opinion On Biological Therapy. 2017. Vol. 17, num. 6, pags. 663-676. ISSN 1471-2598. [consulted: 2 of October of 2026]. Available at: https://hdl.handle.net/2445/164122

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