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2009-09-11

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cc by (c) Rello et al., 2009
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126633

Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain

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https://doi.org/10.1186/cc8044

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Introduction: Patients with influenza A (H1N1)v infection have developed rapidly progressive lower respiratory tract disease resulting in respiratory failure. We describe the clinical and epidemiologic characteristics of the first 32 persons reported to be admitted to the intensive care unit (ICU) due to influenza A (H1N1)v infection in Spain. Methods: We used medical chart reviews to collect data on ICU adult patients reported in a standardized form. Influenza A (H1N1)v infection was confirmed in specimens using real-time reverse transcriptase-polymerase-chain-reaction (RT PCR) assay. Results: Illness onset of the 32 patients occurred between 23 June and 31 July, 2009. The median age was 36 years (IQR = 31 - 52). Ten (31.2%) were obese, 2 (6.3%) pregnant and 16 (50%) had pre-existing medical complications. Twenty-nine (90.6%) had primary viral pneumonitis, 2 (6.3%) exacerbation of structural respiratory disease and 1 (3.1%) secondary bacterial pneumonia. Twenty-four patients (75.0%) developed multiorgan dysfunction, 7 (21.9%) received renal replacement techniques and 24 (75.0%) required mechanical ventilation. Six patients died within 28 days, with two additional late deaths. Oseltamivir administration delay ranged from 2 to 8 days after illness onset, 31.2% received high-dose (300 mg/day), and treatment duration ranged from 5 to 10 days (mean 8.0 +/- 3.3). Conclusions: Over a 5-week period, influenza A (H1N1)v infection led to ICU admission in 32 adult patients, with frequently observed severe hypoxemia and a relatively high case-fatality rate. Clinicians should be aware of pulmonary complications of influenza A (H1N1)v infection, particularly in pregnant and young obese but previously healthy persons.

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Malalties pulmonars obstructives cròniques, Influenzavirus

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Chronic obstructive pulmonary diseases, Influenza viruses

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

RELLO, Jordi, RODRÍGUEZ, Alejandro, IBAÑEZ, Pedro, SOCIAS, Lorenzo, CEBRIAN, Javier, MARQUES, Asunción, GUERRERO, José, RUIZ SANTANA, Sergio, MARQUEZ, Enrique, NOGAL SAEZ, Frutos del, ÁLVAREZ LERMA, Francisco, MARTÍNEZ YÉLAMOS, Sergio, FERRER, Miquel, AVELLANAS, Manuel, GRANADA, Rosa, MARAVÍ POMA, Enrique, ALBERT, Patricia, SIERRA, Rafael, VIDAUR, Loreto, ORTIZ, Patricia, PORTILLO, Isidro prieto del, GALVAN, Beatriz, LEÓN GIL, Cristóbal, H1N1 SEMICYUC Working Group. Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain. _Critical Care_. 2009. Vol. 13, núm. R148. [consulta: 25 de febrer de 2026]. [Disponible a: https://hdl.handle.net/2445/126633]

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