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Circulating soluble adhesion molecules in patients with giant cell arteritis. Correlation between soluble intercellular adhesion molecule-1 (sICAM-1) concentrations and disease activity
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Objective—To evaluate whether changes
in concentrations of circulating adhesion
molecules are related to disease activity in
patients with giant cell arteritis (GCA).
Methods—A sandwich ELISA was used to
measure soluble intercellular adhesion
molecule-1 (sICAM-1), sICAM-3, vascular
cell adhesion molecule-1 (sVCAM-1),
E-selectin (sE-selectin), and L-selectin
(sL-selectin) in serum and plasma samples
from patients with GCA. A cross sectional
study was performed on 64 GCA patients
at diVerent activity stages and on 35 age
and sex matched healthy donors. Thirteen
of these patients were evaluated at the time
of diagnosis and serially during follow up.
Results—At the time of diagnosis,
sICAM-1 concentrations were significantly
higher in active GCA patients than in controls
(mean (SD) 360.55 (129.78) ng/ml versus
243.25 (47.43) ng/ml, p<0.001). In
contrast, sICAM-3, sVCAM-1, sE-selectin,
and sL-selectin values did not diVer from
those obtained in normal donors. With
corticosteroid administration, a decrease
in sICAM-1 concentrations was observed,
reaching normal values when clinical remission
was achieved (263.18 (92.7) ng/ml
globally, 293.59 (108.39) ng/ml in the group
of patients in recent remission, and 236.83
(70.02) ng/ml in those in long term remission).
In the 13 patients followed up
longitudinally, sICAM-1 values also normalised
with clinical remission (225.87
(64.25) ng/ml in patients in recent remission,
and 256.29 (75.15) ng/ml in those in
long term remission).
Conclusions—Circulating sICAM-1 concentrations
clearly correlate with clinically
apparent disease activity in GCA
patients. DiVerences with results previously
found in patients with other vasculitides
may indicate that diVerent
pathogenic mechanisms contribute to
vascular inflammation in diVerent disorders
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COLL-VINENT I PUIG, Blanca, VILARDELL VILA, Carme, FONT, Carme, ORISTRELL SALVÀ, Joaquim, HERNÁNDEZ RODRÍGUEZ, José, YAGÜE, Jordi, URBANO MÁRQUEZ, A. (álvaro), GRAU JUNYENT, Josep m. (josep maria), CID XUTGLÀ, M. cinta. Circulating soluble adhesion molecules in patients with giant cell arteritis. Correlation between soluble intercellular adhesion molecule-1 (sICAM-1) concentrations and disease activity. _Annals of the Rheumatic Diseases_. 1999. Vol. 58, núm. 3, pàgs. 189-192. [consulta: 21 de gener de 2026]. ISSN: 0003-4967. [Disponible a: https://hdl.handle.net/2445/22433]