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2024-11

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cc-by-nc-nd (c) Elsevier Ltd., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/219441

Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode

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https://doi.org/10.1016/j.psyneuen.2024.107112

Resum

Aim: To analyze the clinical, neurocognitive, and functional impact of prolactin levels according to sex in patients with a First Episode Psychosis (FEP). Methods: We measured prolactin levels in 221 non-affective FEP patients treated with antipsychotics (AP) and 224 healthy controls, at baseline and 2-year follow-up. We examined whether the relationships between clinical and functional variables were mediated by prolactin, controlling for antipsychotic use, according to sex. Results: Prolactin levels were higher in patients when compared to controls at both time points. Baseline factors associated with prolactin were chlorpromazine equivalents, attention, and executive functioning. In the FEP group, prolactin levels were associated with functioning and diminished expression in males, and with working memory in females. Prolactin levels (p=0.0134) played a role as a mediator between negative symptomatology (p=0.086) and functional outcome (p=0.008) only in FEP male patients at baseline. Conclusions: Prolactin plays a role in the functionality and clinical symptomatology of FEP patients. Our results suggest that pharmacological counselling in patients with hyperprolactinemia at baseline and negative symptomatology might improve their functional and clinical outcomes.

Matèries

Psicosi, Prolactina, Diferències entre sexes, Símptomes, Antipsicòtics

Matèries (anglès)

Psychoses, Prolactin, Sex differences, Symptoms, Antipsychotic drugs

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))

Citació

JORDÀ BALERI, Teresa, GARRIGA, Marina, MEZQUIDA MATEOS, Gisela, CUESTA, Manuel j., MARTÍNEZ-ARÁN, Anabel, GARCÍA RIZO, Clemente, LOBO, Antonio, GONZÁLEZ-PINTO, Ana, DÍAZ CANEJA, Covadonga m., ROLDÁN, Alexandra, VIETA I PASCUAL, Eduard, BAEZA, Inmaculada, TRABSA, Amira, MONTALVO, Itziar, TORTORELLA, Alfonso, MENCULINI, Giulia, VERDOLINI, Norma, RAMOS QUIROGA, Josep antoni, SÁNCHEZ TORRES, Ana m., BERNARDO ARROYO, Miquel, AMORETTI GUADALL, Silvia, PEPs Group. Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode. _Psychoneuroendocrinology_. 2024. Vol. 169. [consulta: 25 de febrer de 2026]. ISSN: 0306-4530. [Disponible a: https://hdl.handle.net/2445/219441]

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