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2006

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cc-by, (c) Grau et al., 2006
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/7602

Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy

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http://dx.doi.org/10.1186/1477-7819-4-53

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Background: We investigated the change of prognosis in resected gastric cancer (RGC) patients and the role of radical surgery and adjuvant chemotherapy. Methods: We retrospectively analyze the outcome of 426 consecutive patients from 1975 to 2002, divided into 2 time-periods (TP) cohort: Before 1990 (TP1, n = 207) and 1990 or after (TP2; n= 219). Partial gastrectomy and D1-lymphadenetomy was predominant in TP1 and total gastrectomy with D2-lymphadenectomy it was in TP2. Adjuvant chemotherapy consisted of mitomycin C (MMC), 10¿20 mg/m2 iv 4 courses or MMC plus Tegafur 500 mg/m2 for 6 months. Results: Positive nodes were similar in TP2/TP1 patients with 56%/59% respectively. Total gastrectomy was done in 56%/45% of TP2/TP1 respectively. Two-drug adjuvant chemotherapy was administered in 65%/18% of TP2/TP1 respectively. Survival at 5 years was 66% for TP2 versus 42% for TP1 patients (p < 0.0001). Survival by stages II, IIIA y IIIB for TP2 versus TP1 patients was 70 vs. 51% (p = 0.0132); 57 vs. 22% (p = 0.0008) y 30 vs. 15% (p = 0.2315) respectively. Multivariate analysis showed that age, stage of disease and period of treatment were independent variables. Conclusion: The global prognosis and that of some stages have improved in recent years with case RGC patients treated with surgery and adjuvant chemotherapy.

Matèries

Aparell digestiu, Càncer, Quimioteràpia

Matèries (anglès)

Gastric cancer, Chemotherapy

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Articles publicats en revistes (Medicina)

Citació

GRAU, Juan josé, PALMERO, Ramón, MARMOL, Maribel, DOMINGO DOMÈNECH, Josep maria, MONZÓ PLANELLA, Mariano, FUSTER OBREGÓN, Josep, VIDAL PÉREZ, Oscar, FONDEVILA CAMPO, Constantino, GARCÍA-VALDECASAS SALGADO, Juan carlos. Time-related improvement of survival in resectable gastric cancer: the role of Japanese-style gastrectomy with D2 lymphadenectomy and adjuvant chemotherapy. _World Journal of Surgical Oncology_. 2006. Vol. 4, núm. 53. [consulta: 9 de gener de 2026]. ISSN: 1477-7819. [Disponible a: https://hdl.handle.net/2445/7602]

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