Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/171619
Immune biomarkers of response to immune-checkpoint inhibitors in head and neck squamous cell carcinoma
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Anti-programmed cell death protein 1 (PD-1) agents have become the standard of care for platinum-refractory recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) and are currently being evaluated in various disease settings. However, despite the gain in overall survival seen in some of the clinical trials, the majority of patients display primary resistance and do not benefit from these agents. Taking into consideration the potentially severe immune-related toxicities and their high cost, the search for predictive biomarkers of response is crucial. Besides Programmed death ligand-1 (PD-L1) expression, other biomarkers such as immune infiltration, tumor mutational burden or immune-gene expression profiling have been explored, but none of them has been validated in this disease. Among these, the microbiota has recently garnered tremendous interest since it has proven to influence the efficacy of PD-1 blockade in some tumor types. With the accumulating evidence on the effect of the microbiota in HNSCC tumorigenesis and progression, the study of its potential role as a predictive immune biomarker is warranted. This review examines the available evidence on emerging immune predictive biomarkers of response to anti-PD-1/PD-L1 therapy in HNSCC, introducing the microbiota and its potential use as a predictive immune biomarker in this disease.
Matèries
Matèries (anglès)
Citació
Citació
OLIVA, Marc, SPREAFICO, Anna, TABERNA, Miren, ALEMANY I VILCHES, Laia, COBURN, Bryan, MESÍA NIN, Ricard, SIU, Lillian l.. Immune biomarkers of response to immune-checkpoint inhibitors in head and neck squamous cell carcinoma. _Annals Of Oncology_. 2019-01-01. Vol. 30, núm. Issue 1, pàgs. 57-67. [consulta: 27 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/171619]