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2023-01-01

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cc-by (c) Solé-morata, Neus et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/197203

Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variables

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https://doi.org/10.3390/nu15020418

Abstract

Gambling Disorder (GD) has a complex etiology that involves biological and environmental aspects. From a genetic perspective, neurotrophic factors (NTFs) polymorphisms have been associated with the risk of developing GD. The aim of this study was to assess the underlying mechanisms implicated in GD severity by considering the direct and mediational relationship between different variables including genetic, psychological, socio-demographic, and clinical factors. To do so, we used genetic variants that were significantly associated with an increased risk for GD and evaluated its relationship with GD severity through pathway analysis. We found that the interaction between these genetic variants and other different biopsychological features predicted a higher severity of GD. On the one hand, the presence of haplotype block 2, interrelated with haplotype block 3, was linked to a more dysfunctional personality profile and a worse psychopathological state, which, in turn, had a direct link with GD severity. On the other hand, having rs3763614 predicted higher general psychopathology and therefore, higher GD severity. The current study described the presence of complex interactions between biopsychosocial variables previously associated with the etiopathogenesis and severity of GD, while also supporting the involvement of genetic variants from the NTF family.

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Joc compulsiu, Psicopatologia, Personalitat, Genètica

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Compulsive gambling, Pathological psychology, Personality, Genetics

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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SOLÉ MORATA, Neus, et al. Underlying mechanisms involved in gambling disorder severity: a pathway analysis considering genetic, psychosocial, and clinical variables. Nutrients. 2023. Vol. 15, num. 2. ISSN 2072-6643. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/197203

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