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2017-04-24

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cc by (c) Chaccour et al., 2017
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/110768

Ivermectin to reduce malaria transmission I. Pharmacokinetic and pharmacodynamic considerations regarding efficacy and safety

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http://dx.doi.org/10.1186/s12936-017-1801-4

Abstract

Ivermectin is an endectocide that has been used broadly in single dose community campaigns for the control of onchocerciasis and lymphatic filariasis for more than 30 years. There is now interest in the potential use of ivermectin regimens to reduce malaria transmission, envisaged as community-wide campaigns tailored to transmission patterns and as complement of the local vector control programme. The development of new ivermectin regimens or other novel endectocides will require integrated development of the drug in the context of traditional entomological tools and endpoints. This document examines the main pharmacokinetic and pharmacodynamic parameters of the medicine and their potential influence on its vector control efficacy and safety at population level. This information could be valuable for trial design and clinical development into regulatory and policy pathways.

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Malària, Medicina tropical, Farmacocinètica

Subject (English)

Malaria, Tropical medicine, Pharmacokinetics

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Articles publicats en revistes (ISGlobal)

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CHACCOUR, Carlos, HAMMANN, Felix and RABINOVICH, Regina. Ivermectin to reduce malaria transmission I. Pharmacokinetic and
                pharmacodynamic considerations regarding efficacy and safety. Malaria Journal. 2017. Vol. 16, num. 1, pags. 161. ISSN 1475-2875. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/110768

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