Miniatura

Fitxers

asymptomatic_inflammatory_bowel_disease_diagnosed.5.pdf (300.19 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2025-02

Llicència de publicació

cc-by-nc-nd (c) Brunet Mas et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/221342

Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural history

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.14309/ctg.0000000000000740

Resum

INTRODUCTION:Inflammatory bowel disease (IBD) is usually diagnosed when symptomatic. Prognosis and evolution of preclinical IBD is largely unknown. However, colorectal cancer screening programs (CRCSP) detect a subset of patients with IBD with no symptoms. The aim of this study was to describe the natural history of asymptomatic IBD diagnosed through CRCSP. METHODS:An observational, longitudinal, and retrospective study was performed at 22 centers in Catalonia between January 2010 and December 2019 including patients with asymptomatic IBD detected in the CRCSP. Demographic data and IBD characteristics, evolution, and treatment were recorded. Descriptive statistics and Kaplan-Meier analysis were used for the analysis. Data were given separately for IBD, Crohn's disease (CD), ulcerative colitis (UC), and IBD unclassified (IBDU). RESULTS:One hundred eighty-eight patients were included: 103 UC (54.8%), 60 CD (31.9%), and 25 IBDU (13.3%). Sixty-six (35.1%) were women, and the average age was 59.9 +/- 5.9 years. Sixty-four patients (34.0%) developed symptoms after a median follow-up of 35.6 months. Diarrhea was the most frequent symptom for CD and IBDU (25.4% and 11.5%, respectively) and blood in stools for UC (21.4%). The median time to first symptom was 11.6 months. Treatment was prescribed in 135 patients (72.2%); mesalazine was the most prescribed drug (123 patients; 65.4%). Thirteen patients (6.9%) required biological treatment. None underwent surgery. DISCUSSION:Around one-third of asymptomatic patients with IBD developed symptoms after a medium follow-up of 3 years. Only 6.9% required biological treatment, and none required surgery. Overall, prognosis of asymptomatic IBD seems better.

Matèries

Malalties inflamatòries intestinals, Malaltia de Crohn, Colitis ulcerosa

Matèries (anglès)

Inflammatory bowel diseases, Crohn's disease, Ulcerative colitis

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BRUNET MAS, Eduard, SELVA, Anna, BAS-CUTRINA, Francesc, BRUJATS, Anna, CABALLOL, Berta, FONT, Rebeca, GÓMEZ, Bàrbara, GONZALEZ MUÑOSA, Carlos, BUSQUETS, David, MONFORT, David, VERA, Diana patrícia, MARISTANY, Elisabet, CIRERA, Gemma, TORRES, Gisela, CASTRO POCEIRO, Jesús, LÓPEZ, Joel, GONZALEZ GONZALEZ, Laura, MÀRQUEZ MOSQUERA, Lucia, GALLACH, Marta, ESTEVE, Maria, TREMOSA, Gemma, TORRA, Sandra, ROBLES ALONSO, Virginia, GARCÍA IGLESIAS, Pilar, RODRÍGUEZ LAGO, Iago, CALVET, Xavier. Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural history. _Clinical and Translational Gastroenterology_. 2024. Vol. 16, núm. 2. [consulta: 15 de gener de 2026]. ISSN: 2155-384X. [Disponible a: https://hdl.handle.net/2445/221342]

Exportar metadades

JSON - METS

Compartir registre