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s13058-025-02142-2.pdf (1.11 MB)

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2025-10-24

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cc-by (c) Fernández Morata, Julia et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/224346

Mammographic density and breast cancer pathological subtypes by menopausal status and body mass index

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https://doi.org/10.1186/s13058-025-02142-2

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Background Mammographic density (MD) is an established biomarker of breast cancer (BC) risk. However, its relationship to BC pathological subtypes remains unclear. This study aimed to investigate this association and assess whether it differs by body mass index (BMI) and menopausal status. Methods MD percentage was assessed in the diagnostic mammograms of the contralateral breast of 714 BC patients recruited from eight Spanish hospitals. Participants completed an epidemiological questionnaire, and hospital researchers collected clinical and pathological data. Standardized prevalences (SPs) and standardized prevalence ratios (SPRs) for each BC pathological subtype across MD categories were estimated based on multinomial logistic regression models, both overall and stratified by BMI and menopausal status. Results Mean MD was 26.1% (SD = 17.3). Although no statistically significant differences were detected, women with MD >= 50% had a 13% lower SP of hormone receptor positive tumors (SPR = 0.87; 95% CI 0.67-1.13), a 36% higher SP of human epidermal growth factor receptor 2 positive (HER2+) tumors (SPR = 1.36; 95% CI 0.72-2.58), and a 23% higher SP of triple negative (TN) tumors (SPR = 1.23; 95% CI 0.47-3.22), compared to those with MD < 10%. These patterns were mainly observed in pre/perimenopausal women and in those with BMI >= 25 kg/m(2). Conclusions High MD might be mainly associated with the development of more aggressive and non-hormone-dependent cancers, such as HER2+ and TN BC, especially among pre/perimenopausal an overweight women.

Matèries

Càncer de mama, Classificació de tumors, Mamografia

Matèries (anglès)

Breast cancer, Tumors classification, Mammography

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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FERNÁNDEZ MORATA, Julia, POLLÁN, Marina, FERNÁNDEZ DE LARREA BAZA BAZ, Nerea, PACHÓN OLMOS, Vanessa, GARCÍA PÉREZ, Javier, CASTELLÓ, Adela, SIERRA, Maria angeles, LUCAS, Pilar, LLOBET, Rafael, STRADELLA, Agostina, CANTOS, Blanca, RAMÓN Y CAJAL, Teresa, SANTISTEBAN, Marta, ÁNGEL SEGUÍ, Miguel, SANTABALLA BERTRÁN, Ana, GRANJA, Mónica, CAMPS HERRERO, Julia, RECALDE, Sabela, NUÑEZ GARCÍA, Beatriz, CALVO VERGES, Nuria, PÉREZ-GÓMEZ, Beatriz, PASTOR BARRIUSO, Roberto, LOPE, Virginia. Mammographic density and breast cancer pathological subtypes by menopausal status and body mass index. _Breast Cancer Research_. 2025. Vol. 27, núm. 187. [consulta: 27 de gener de 2026]. ISSN: 1465-542X. [Disponible a: https://hdl.handle.net/2445/224346]

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