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2014-06-08

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cc-by (c) Mesquida, Marina et al., 2014
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/119678

Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease

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https://doi.org/10.1155/2014/396204

Resum

The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behcet's disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-gamma (IFN-gamma), interleukin-1 beta (IL-1 beta), IL-12p70, IL-17A, tumor necrosis factor-alpha (TNF-alpha), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-gamma and TNF-alpha were significantly increased in patients with active uveitis associated to BD compared to controls (P < 0.05). IFN-gamma, TNF-alpha, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P < 0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P < 0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-gamma, TNF-alpha, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.

Matèries

Citoquines, Proteïnes de la sang, Uveïtis, Malaltia de Behçet, Inflamació

Matèries (anglès)

Cytokines, Blood proteins, Uveitis, Behçet's disease, Inflammation

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

MESQUIDA, Marina, et al. Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease. Mediators of Inflammation. 2014. Vol. 2014. ISSN 0962-9351. [consulted: 4 of June of 2026]. Available at: https://hdl.handle.net/2445/119678

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