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Data de publicació

2026-01-19

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cc-by (c) Zimkowska K et al., 2026
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/226761

Neuromechanobiology: Bridging Mechanobiology and Neuroscience Through Evidence and Open Questions

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Recurs relacionat

https://doi.org/10.3390/cells15020178

Resum

Neuromechanobiology has emerged as a multidisciplinary field at the interface of neuroscience and mechanobiology, aiming to elucidate how mechanical forces influence the development, organization, and function of the nervous system. This review offers a comprehensive overview of the historical evolution of the discipline, its molecular and biophysical foundations, and the experimental strategies employed to investigate it. Recent advances have revealed the pivotal roles of substrate stiffness, mechanical signaling, and force transduction in neural stem proliferation, axon guidance, synapse formation, and neural circuit maturation. All these effects originate at the molecular level and extend to the mesoscopic scale. Disrupted mechanotransduction has been increasingly implicated in neurodevelopmental disorders and neurodegenerative diseases, underscoring its clinical relevance. Key unresolved questions and future directions are also highlighted, with emphasis on the need for integrative approaches to decipher the complex interplay between mechanical forces and neural function.

Matèries

Neurobiologia, Neurociències, Cervell

Matèries (anglès)

Neurobiology, Neurosciences, Brain

Citació

Col·leccions

Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut de Neurociències (UBNeuro))

Citació

ZIMKOWSKA, Karolina, RIU-VILLANUEVA, Marc and RÍO FERNÁNDEZ, José Antonio del. Neuromechanobiology: Bridging Mechanobiology and Neuroscience Through Evidence and Open Questions. Cells. 2026. Vol. 15, num. 2, pags. 178-214. ISSN 2073-4409. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/226761

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