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2015-08-14

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cc-by (c) Rothwell, Joseph A. et al., 2015
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/107940

Systematic analysis of the polyphenol metabolome using the Phenol-Explorer database

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https://doi.org/10.1002/mnfr.201500435

Abstract

SCOPE: The Phenol-Explorer web database details 383 polyphenol metabolites identified in human and animal biofluids from 221 publications. Here we exploit these data to characterize and visualize the polyphenol metabolome, the set of all metabolites derived from phenolic food components. METHODS AND RESULTS: Qualitative and quantitative data on 383 polyphenol metabolites as described in 424 human and animal intervention studies were systematically analyzed. Of these metabolites, 301 were identified without prior enzymatic hydrolysis of biofluids, and included glucuronide and sulfate esters, glycosides, aglycones, and O-methyl ethers. Around one third of these compounds are also known as food constituents and corresponded to polyphenols absorbed without further metabolism. Many ring-cleavage metabolites formed by gut microbiota were noted, mostly derived from hydroxycinnamates, flavanols and flavonols. Median maximum plasma concentrations (Cmax ) of all human metabolites were 0.09 μM and 0.32 μM when consumed from foods or dietary supplements respectively. Median time to reach maximum plasma concentration in humans (Tmax ) was 2.18 h. CONCLUSION: These data show the complexity of the polyphenol metabolome and the need to take into account biotransformations to understand in vivo bioactivities and the role of dietary polyphenols in health and disease. This article is protected by copyright. All rights reserved.

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Biodisponibilitat, Metabolisme, Farmacocinètica, Polifenols, Metabòlits, Consum d'aliments

Subject (English)

Bioavailability, Metabolism, Pharmacokinetics, Polyphenols, Metabolites, Food consumption

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Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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ROTHWELL, Joseph A., et al. Systematic analysis of the polyphenol metabolome using the Phenol-Explorer database. Molecular Nutrition & Food Research. 2015. Vol. 60, num. 1, pags. 203-211. ISSN 1613-4125. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/107940

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