Miniatura

Fitxers

febs.14608.pdf (1006.73 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2018-08-04

Llicència de publicació

cc by (c) Almanza et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/174974

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1111/febs.14608

Resum

The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the production and folding of approximately one-third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. Specific ER stress signalling pathways, collectively known as the unfolded protein response (UPR), are required for maintaining ER homeostasis. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. In this review, we provide a UPR signalling-centric view of ER functions, from the ER's discovery to the latest advancements in the understanding of ER and UPR biology. Our review provides a synthesis of intracellular ER signalling revolving around proteostasis and the UPR, its impact on other organelles and cellular behaviour, its multifaceted and dynamic response to stress and its role in physiology, before finally exploring the potential exploitation of this knowledge to tackle unresolved biological questions and address unmet biomedical needs. Thus, we provide an integrated and global view of existing literature on ER signalling pathways and their use for therapeutic purposes.

Matèries

Reticle endoplasmàtic, Proteòmica

Matèries (anglès)

Endoplasmic reticulum, Proteomics

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

ALMANZA, Aitor, CARLESSO, Antonio, CHINTHA, Chetan, CREEDICAN, Stuart, DOULTSINOS, Dimitrios, LEUZZI, Brian, LUÍS, Andreia, MCCARTHY, Nicole, MONTIBELLER, Luigi, MORE, Sanket, PAPAIOANNOU, Alexandra, PÜSCHEL, Franziska, SASSANO, Maria livia, SKOKO, Josip, AGOSTINIS, Patrizia, BELLEROCHE, Jackie de, ERIKSSON, Leif a., FULDA, Simone, GORMAN, Adrienne m., HEALY, Sandra, KOZLOV, Andrey, MUÑOZ PINEDO, Cristina, REHM, Markus, CHEVET, Eric, SAMALI, Afshin. Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications. _The FEBS Journal_. 2018. Vol. 286, núm. 2, pàgs. 241-278. [consulta: 25 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/174974]

Exportar metadades

JSON - METS

Compartir registre