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2020-11-05

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cc-by (c) Izquierdo, Conchita et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/195333

Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era

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https://doi.org/10.1017/S0950268820002708

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The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study (January 2012-June 2016). IPD cases were diagnosed by culture and/or real-time polymerase chain reaction (PCR). Demographic, microbiological and clinical data were analysed. Associations were assessed using the odds ratio (OR) and 95% confidence intervals (CI). Of the 253 cases, 34.4% were aged <2 years, 38.7% 2-4 years and 26.9% 5-17 years. Over 64% were 13-valent pneumococcal conjugate vaccine (PCV13) serotypes. 48% of the cases were diagnosed only by real-time PCR. Serotypes 3 and 1 were associated with complicated pneumonia (P < 0.05) and non-PCV13 serotypes with meningitis (OR 7.32, 95% CI 2.33-22.99) and occult bacteraemia (OR 3.6, 95% CI 1.56-8.76). Serotype 19A was more frequent in children aged <2 years and serotypes 3 and 1 in children aged 2-4 years and 5-17 years, respectively. 36.1% of cases were not susceptible to penicillin and 16.4% were also non-susceptible to cefotaxime. Serotypes 14, 24F and 23B were associated with non-susceptibility to penicillin (P < 0.05) and serotypes 11, 14 and 19A to cefotaxime (P < 0.05). Serotype 19A showed resistance to penicillin (P = 0.002). In conclusion, PCV13 serotypes were most frequent in children aged ⩽17 years, mainly serotypes 3, 1 and 19A. Non-PCV13 serotypes were associated with meningitis and occult bacteraemia and PCV13 serotypes with pneumonia. Non-susceptibility to antibiotics of non-PCV13 serotypes should be monitored.

Matèries

Infants, Infeccions per pneumococs, Vacuna antipneumocòccica, Pneumococs, Penicil·lina, Identificació dels microoganismes

Matèries (anglès)

Children, Pneumococcal Infections, Pneumococcal vaccine, Streptococcus pneumonia, Penicillin, Microorganisms identification

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Articles publicats en revistes (Medicina)

Citació

IZQUIERDO, Conchita, CIRUELA, Pilar, HERNÁNDEZ, Sergi, GARCÍA GARCÍA, Juan josé, ESTEVA, Cristina, MORAGA LLOP, Fernando a., DÍAZ CONRADI, Álvaro, MARTÍNEZ OSORIO, Johanna, SOLÉ RIBALTA, Anna, FERNÁNDEZ DE SEVILLA ESTRACH, Mariona, GONZÁLEZ-PERIS, Sebastià, CODINA GRAU, Maria gemma, PLANES, Ana maría, URIONA, Sonia, CAMPINS MARTÍ, Magda, MUÑOZ ALMAGRO, Carmen, SALLERAS I SANMARTÍ, Lluís, DOMÍNGUEZ GARCÍA, Àngela. Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era. _Epidemiology and Infection_. 2020. Vol. 148, núm. e279. [consulta: 23 de gener de 2026]. ISSN: 0950-2688. [Disponible a: https://hdl.handle.net/2445/195333]

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