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2025-01-01

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cc-by (c) Bescós García et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/221287

Nitrate and nitrite bioavailability in plasma and saliva: their association with blood pressure — A systematic review and meta-analysis

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Recurs relacionat

https://doi.org/10.1016/j.freeradbiomed.2024.11.010

Resum

In this study, we conducted a systematic review and meta-analysis to determine plasma and salivary nitrate (NO3-) and nitrite (NO2-) concentrations under resting and fasting conditions in different type of individuals and their association with blood pressure levels. A total of 77 studies, involving 1918 individuals aged 19-74 years (males = 906; females = 1012), which measured plasma and/or salivary NO3- and NO2- using the chemiluminescence technique, were included. Mean plasma NO3- and NO2- concentrations were 33.9 mu mol/L and 158.3 nmol/L, respectively. Subgroup analyses revealed lower plasma NO3- and NO2- concentrations in individuals with cardiometabolic risk (NO3-: 21.2 mu mol/L; 95 % CI, 13.4-29.0; NO2-: 122.8 nmol/L; 95 % CI, 75.3-138.9) compared to healthy (NO3-: 33.9 mu mol/L; 95 % CI, 29.9-37.9; NO2-: 159.5 nmol/L; 95 % CI, 131.8-187.1; P < 0.01) and trained individuals (NO3-: 43.0 mu mol/L; 95 % CI, 13.2-72.9; NO2-: 199.3 nmol/L; 95 % CI, 117.6-281; P < 0.01). Mean salivary NO3- and NO2- concentrations were 546.2 mu mol/L and 197.8 mu mol/L, respectively. Salivary NO3-, but no NO2-, concentrations were higher in individuals with cardiometabolic risk (680.0 mu mol/L; 95 % CI, 510.2-849.8; P = 0.001) compared to healthy individuals (535.9 mu mol/L; 95 % CI, 384.2-687.6). A significant positive association (coefficient, 15.4 [95 % CI, 0.255 to 30.5], P = 0.046) was observed between salivary NO3- and diastolic blood pressure (DBP). These findings suggest that the health status is positively associated with plasma NO3- and NO2- concentrations, but the circulatory levels of these anions are not associated with blood pressure. Only salivary NO3- showed a significant positive association with DBP.

Matèries

Nitrats, Nitrits, Pressió sanguínia

Matèries (anglès)

Nitrates, Nitrites, Blood pressure

Citació

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BESCÓS GARCÍA, Raúl, et al. Nitrate and nitrite bioavailability in plasma and saliva: their association with blood pressure — A systematic review and meta-analysis. Free Radical Biology and Medicine. 2025. Vol. 226, num. 70-83. ISSN 1873-4596. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/221287

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