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1994

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/22459

Antibodies to endothelial cells in Behçet's disease: cell-binding heterogeneity and association with clinical activity

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Recurs relacionat

http://dx.doi.org/10.1136/ard.53.4.265

Resum

OBJECTIVES--To investigate the prevalence and characteristics of antibodies to endothelial cells (aEC) from large vessel and from microvasculature in a group of patients with Behçet's disease (BD) to determine the relationship of these antibodies with clinical and laboratory features of the disease. METHODS--Thirty patients with BD were prospectively and consecutively studied. The aEC were determined by enzyme-linked immunosorbent assay (ELISA) using endothelial cells derived from human umbilical vein (large vessel) as well as from retroperitoneal adipose tissue (microvasculature). RESULTS--Fifteen patients (50%) had aEC, either directed to large vessel [8(26%) patients] or microvascular [13(43%) patients] endothelial cells. The percentage of active patients was significantly higher in the aEC-positive group [12(80%) patients] compared with the aEC-negative group [5(33%) patients] (p < 0.05). CONCLUSIONS--Patients with BD have a high prevalence of aEC when microvascular endothelial cells are used in the assay. These antibodies seem to be a marker of disease activity in this condition, previously considered as negative for autoantibodies.

Matèries

Malaltia de Behçet, Endoteli, Autoanticossos, Immunoglobulines

Matèries (anglès)

Behçet's disease, Endothelium, Autoantibodies, Immunoglobulins

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Articles publicats en revistes (Medicina)

Citació

CERVERA I SEGURA, Ricard, et al. Antibodies to endothelial cells in Behçet's disease: cell-binding heterogeneity and association with clinical activity. Annals of the Rheumatic Diseases. 1994. Vol. 53, num. 4, pags. 265-267. ISSN 0003-4967. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/22459

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