Fitxers

101197.pdf (584.16 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

1994

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/22459

Antibodies to endothelial cells in Behçet's disease: cell-binding heterogeneity and association with clinical activity

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

http://dx.doi.org/10.1136/ard.53.4.265

Resum

OBJECTIVES--To investigate the prevalence and characteristics of antibodies to endothelial cells (aEC) from large vessel and from microvasculature in a group of patients with Behçet's disease (BD) to determine the relationship of these antibodies with clinical and laboratory features of the disease. METHODS--Thirty patients with BD were prospectively and consecutively studied. The aEC were determined by enzyme-linked immunosorbent assay (ELISA) using endothelial cells derived from human umbilical vein (large vessel) as well as from retroperitoneal adipose tissue (microvasculature). RESULTS--Fifteen patients (50%) had aEC, either directed to large vessel [8(26%) patients] or microvascular [13(43%) patients] endothelial cells. The percentage of active patients was significantly higher in the aEC-positive group [12(80%) patients] compared with the aEC-negative group [5(33%) patients] (p < 0.05). CONCLUSIONS--Patients with BD have a high prevalence of aEC when microvascular endothelial cells are used in the assay. These antibodies seem to be a marker of disease activity in this condition, previously considered as negative for autoantibodies.

Matèries

Malaltia de Behçet, Endoteli, Autoanticossos, Immunoglobulines

Matèries (anglès)

Behçet's disease, Endothelium, Autoantibodies, Immunoglobulins

Citació

Col·leccions

Articles publicats en revistes (Medicina)

Citació

CERVERA I SEGURA, Ricard, et al. Antibodies to endothelial cells in Behçet's disease: cell-binding heterogeneity and association with clinical activity. Annals of the Rheumatic Diseases. 1994. Vol. 53, num. 4, pags. 265-267. ISSN 0003-4967. [consulted: 6 of July of 2026]. Available at: https://hdl.handle.net/2445/22459

Exportar metadades

JSON - METS

Compartir registre