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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/181054
Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly
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Aims/hypothesis: Midlife obesity is a risk factor for dementia. We investigated the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) core Alzheimer's disease (AD) biomarkers in healthy elderly. Methods: We selected controls from ADNI2 with CSF AD biomarkers and/or fluorodeoxyglucose positron emission tomography (FDG-PET) and 3T-MRI. We measured cortical thickness, FDG uptake, and CSF amyloid beta (Aβ)1-42, p-tau, and t-tau levels. We performed regression analyses between these biomarkers and body mass index (BMI). Results: We included 201 individuals (mean age 73.5 years, mean BMI 27.4 kg/m2). Higher BMI was related to less cortical thickness and higher metabolism in brain areas typically not involved in AD (family-wise error [FWE] <0.05), but not to AD CSF biomarkers. It is notable that the impact of obesity on brain metabolism and structure was also found in amyloid negative individuals. Conclusions/interpretation: In the cognitively unimpaired elderly, obesity has differential effects on brain metabolism and structure independent of an underlying AD pathophysiology.
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PEGUEROLES, Jordi, PANÉ, Adriana, VILAPLANA, Eduard, MONTAL, Victor, BEJANIN, Alexandre, VIDELA, Laura, CARMONA IRAGUI, María, BARROETA, Isabel, IBARZABAL, Ainitze, CASAJOANA, Anna, ALCOLEA, Daniel, VALLDENEU, Silvia, ALTUNA, Miren, HOLLANDA RAMÍREZ, Ana m. de, VIDAL I CORTADA, Josep, ORTEGA MARTÍNEZ DE VICTORIA, Emilio, OSORIO, Ricardo, CONVIT, Antonio, BLESA GONZÁLEZ, Rafael, LLEÓ BISA, Alberto, FORTEA ORMAECHEA, Juan, JIMÉNEZ PINEDA, Amanda, Alzheimer's Disease Neuroimaging Initiative. Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly. _Alzheimer's & Dementia: Diagnosis_. Assessment & Disease Monitoring. Vol. 2020, núm. 12, pàgs. 1. [consulta: 23 de gener de 2026]. ISSN: 2352-8729. [Disponible a: https://hdl.handle.net/2445/181054]