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annamalay2016_2169.pdf (270.97 KB)

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2016-07-26

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/101573

Rhinovirus Species and Clinical Features in Children Hospitalized with Pneumonia from Mozambique

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http://dx.doi.org/10.1111/tmi.12743

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OBJECTIVES: To describe the prevalence of human rhinovirus (RV) species in children hospitalized with pneumonia in Manhica, Mozambique; and the associations between RV species and demographic, clinical, and laboratory features. METHODS: Nasopharyngeal aspirates were collected from children 0-10 years of age (n=277) presenting to Manhica District Hospital with clinical pneumonia. Blood samples were collected for HIV and malaria testing, blood culture and full blood counts, and a chest X-ray was performed. A panel of common respiratory viruses was investigated using two independent multiplex RT-PCR assays with primers specific for each virus and viral type. RV species and genotypes were identified by semi-nested PCR assays, sequencing and phylogenetic tree analyses. RESULTS: At least one respiratory virus was identified in 206 (74.4%) children hospitalized with clinical pneumonia. RV was the most common virus identified in both HIV-infected (17/38, 44.7%) and HIV-uninfected (74/237, 31.2%; p=0.100) children. RV-A was the most common RV species identified (47/275, 17.0%), followed by RV-C (35/275, 12.6%) and RV-B (8/275, 2.9%). Clinical presentation of the different RV species was similar and overlapping, with no particular species being associated with specific clinical features. CONCLUSIONS: RV-A and RV-C were the most common respiratory viruses identified in children hospitalised with clinical pneumonia in Manhica. Clinical presentation of RV-A and RV-C was similar and overlapping. This article is protected by copyright. All rights reserved.

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Pneumònia, Infants, Moçambic

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Pneumonia, Children, Mozambique

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ANNAMALAY, Alicia a., LANASPA, Miguel, KHOO, Siew-kim, MADRID, Lola, ACÁCIO, Sozinho, ZHANG, Guicheng, LAING, Ingrid, GERN, James, GOLDBLATT, Jack, BIZZINTINO, Joelene, LEHMANN, Deborah, LE SOUEF, Peter n., BASSAT ORELLANA, Quique. Rhinovirus Species and Clinical Features in Children
                Hospitalized with Pneumonia from Mozambique. _Tropical Medicine & International Health_. 2016. [consulta: 23 de gener de 2026]. ISSN: 1360-2276. [Disponible a: https://hdl.handle.net/2445/101573]

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