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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/190795
Beta-blocker use in patients with heart failure with preserved ejection fraction and sinus rhythm
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Introduction: Beta-adrenergic receptor blockers (beta-blockers) are frequently used for patients with heart failure (HF) with preserved ejection fraction (HFpEF), although evidence-based recommendations for this indication are still lacking. Our goal was to assess which clinical factors are associated with the prescription of beta-blockers in patients discharged after an episode of HFpEF decompensation, and the clinical outcomes of these patients. Methods: We assessed 1078 patients with HFpEF and in sinus rhythm who had experienced an acute HF episode to explore whether prescription of beta-blockers on discharge was associated with one-year all-cause mortality or the composite endpoint of one-year all-cause death or HF readmission. We also examined the clinical factors associated with beta-blocker discharge prescription for such patients. Results: At discharge, 531 (49.3%) patients were on beta-blocker therapy. Patients on beta-blockers more often had a prior diagnosis of hypertension and more comorbidity (including ischemic heart disease) and a better functional status, but less often a prior diagnosis of chronic obstructive pulmonary disease. These patients had a lower heart rate on admission and more often used angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, angiotensin receptor-neprilysin inhibitors and loop diuretics. One year after the index admission, 161 patients (15%) had died and 314 (29%) had experienced the composite endpoint. After multivariate adjustment, beta-blocker prescription was not associated with either all-cause mortality (HR=0.83 [95% CI 0.61-1.13]; p=0.236) or the composite endpoint (HR=0.98 [95% CI 0.79-1.23]; p=0.882). Conclusion: In patients with HFpEF in sinus rhythm, beta-blocker use was not related to one-year mortality or mortality plus HF readmission.
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FORMIGA PÉREZ, Francesc, CHIVITE, David, NUÑEZ, Julio, MORENO GARCÍA, Ma. carmen, MANZANO, Luis, ARÉVALO-LORIDO, José carlos, CERQUEIRO, Jose manuel, GARCÍA CAMPOS, Álvaro, TRULLÀS, Joan carles, MONTERO PÉREZ-BARQUERO, Manuel. Beta-blocker use in patients with heart failure with preserved ejection fraction and sinus rhythm. _Revista Portuguesa de Cardiologia_. 2022. Vol. 41, núm. 10, pàgs. 853-861. [consulta: 28 de gener de 2026]. ISSN: 0870-2551. [Disponible a: https://hdl.handle.net/2445/190795]