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Molecular Epidemiology of Klebsiella pneumoniae Strains Causing Bloodstream Infections in Adults
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Molecular epidemiology of Klebsiella pneumoniae bacteremic strains allows for a better understanding of preventive and therapeutic strategies. Clinical and microbiological characteristics of 348 K. pneumoniae bacteremia cases (2007-2009) were retrospectively characterized by multilocus sequence typing and extended-spectrum beta-lactamases (ESBL) production. Overall, 223 (64.08%) cases were nosocomial (NA), 58 (16.67%) healthcare associated, and 67 (19.25%) community acquired. The main infection origins were urinary tract (16.6%, 50.0%, and 43.3%), biliary tract (10.8%, 24.2%, and 31.3%), and catheter-related infection (39.9%, 5.2%, and 0%). The 30-day mortality rate was around 20%. The rates of resistance were around 45% the highest being among NA cases, and ESBL production was detected in 7.2% of cases. A total of 161 different sequence types were grouped into 13 clonal sets by e-burst analysis. No relationship could be established between clonal sets and the origin of infection or the healthcare-related settings. The high genetic variability among the isolates suggests their intrapatient endogenous origin.
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CUBERO, Meritxell, GRAU, Immaculada, TUBAU, Fe, PALLARÉS GINER, Roman, DOMÍNGUEZ LUZÓN, Ma. ángeles (maría ángeles), LIÑARES LOUZAO, Josefina, ARDANUY TISAIRE, María carmen. Molecular Epidemiology of Klebsiella pneumoniae Strains Causing Bloodstream Infections in Adults. _Microbial Drug Resistance_. 2018. Vol. 24, núm. 7, pàgs. 949-957. [consulta: 22 de febrer de 2026]. ISSN: 1076-6294. [Disponible a: https://hdl.handle.net/2445/177690]