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Dynamic model of the left ventricle for use in simulation of myocardial perfusion SPECT and gated SPECT
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Simulation is a useful tool in cardiac SPECT to assess quantification algorithms. However, simple equation-based models are limited in their ability to simulate realistic heart motion and perfusion. We present a numerical dynamic model of the left ventricle, which allows us to simulate normal and anomalous cardiac cycles, as well as perfusion defects. Bicubic splines were fitted to a number of control points to represent endocardial and epicardial surfaces of the left ventricle. A transformation from each point on the surface to a template of activity was made to represent the myocardial perfusion. Geometry-based and patient-based simulations were performed to illustrate this model. Geometry-based simulations modeled ~1! a normal patient, ~2! a well-perfused patient with abnormal regional function, ~3! an ischaemic patient with abnormal regional function, and ~4! a patient study including tracer kinetics. Patient-based simulation consisted of a left ventricle including a realistic shape and motion obtained from a magnetic resonance study. We conclude that this model has the potential to study the influence of several physical parameters and the left ventricle contraction in myocardial perfusion SPECT and gated-SPECT studies.
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BULLICH ROIG, Santiago, et al. Dynamic model of the left ventricle for use in simulation of myocardial perfusion SPECT and gated SPECT. Medical Physics. 2003. Vol. 30, num. 8, pags. 1968-1975. ISSN 0094-2405. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/24865