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2021_MatSciEngC_EngineeredMicro_Engel_Postprint.pdf (1.54 MB)

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2021-02-01

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cc by-nc-nd (c) Elsevier, 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/184321

Engineered microtissues for the bystander therapy against cancer

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Recurs relacionat

https://doi.org/10.1016/j.msec.2020.111854

Resum

Thymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this strategy requires multiple TK-hAMSCs administrations and a substantial number of cells. Therefore, for clinical translation, it is necessary to find a biocompatible scaffold providing TK-hAMSCs retention in the implantation site against their rapid wash-out. We have developed a microtissue (MT) composed by TKhAMSCs and a scaffold made of polylactic acid microparticles and cell-derived extracellular matrix deposited by hAMSCs. The efficacy of these MTs as vehicles for TK-hAMSCs/GCV bystander therapy was evaluated in a rodent model of human prostate cancer. Subcutaneously implanted MTs were integrated in the surrounding tissue, allowing neovascularization and maintenance of TK-hAMSCs viability. Furthermore, MTs implanted beside tumors allowed TK-hAMSCs migration towards tumor cells and, after GCV administration, inhibited tumor growth. These results indicate that TK-hAMSCs-MTs are promising cell reservoirs for clinical use of therapeutic MSCs in bystander therapies.

Matèries

Nanomedicina, Càncer

Matèries (anglès)

Nanomedicine, Cancer

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Col·leccions

Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
<b>Publicacions de projectes de recerca finançats per la UE</b>

Citació

BLANCO FERNÁNDEZ, Bárbara, GARRIDO, Cristina, RUBÍ SANS, Gerard, SÁNCHEZ CID, Lourdes, GUERRA REBOLLO, Marta, RUBIO VIDAL, Núria, MATEOS TIMONEDA, Miguel ángel, ENGEL, Elisabeth, PÉREZ AMODIO, Soledad. Engineered microtissues for the bystander therapy against cancer. _Materials Science & Engineering C-Materials For Biological Applications_. 2021. Vol.  vol 121. [consulta: 23 de gener de 2026]. ISSN: 0928-4931. [Disponible a: https://hdl.handle.net/2445/184321]

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