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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/173634
Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
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There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality.
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ABUÍN, Jose, TAPIA GUERRERO, María josé, LÓPEZ URDIALES, Rafael, HERRANZ ANTOLÍN, Sandra, GARCÍA ALMEIDA, Jose m., GARCÍA MALPARTIDA, Katherine, FERRER GÓMEZ, Mercedes, CANCER MINCHOT, Emilia, LUENGO PÉREZ, Luis miguel, ÁLVAREZ HERNÁNDEZ, Julia, ARAGÓN VALERA, Carmen, OCÓN BRETÓN, Julia, GARCÍA MANZANARES, Álvaro, BRETÓN LESMES, Irene, SERRANO AGUAYO, Pilar, PÉREZ FERRE, Natalia, LÓPEZ GÓMEZ, Juan josé, OLIVARES ALCOLEA, Josefina, ARRAIZA IRIGOYEN, Carmen, TEJERA PÉREZ, Cristina, MARTÍNEZ GONZÁLEZ, Jorge daniel, URIOSTE FONDO, Ana, ABAD GONZÁLEZ, Ángel luis, MOLINA PUERTA, María josé, ZUGASTI MURILLO, Ana, PARRA BARONA, Juan, LÓPEZ COBO, Irela, OLVEIRA, Gabriel. Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study. _Nutrients_. 2020. Vol. 12, núm. 6. [consulta: 20 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/173634]