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fcell-08-621070.pdf (1.99 MB)

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Versió publicada

Data de publicació

2021-01-22

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cc by (c) Linares et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/174366

Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy

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Recurs relacionat

https://doi.org/10.3389/fcell.2020.621070

Resum

Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represented in the TME and are continuously interacting with cancer cells. CAFs are regulating key mechanisms during progression to metastasis and response to treatment by enhancing cancer cells survival and aggressiveness. The latest advances in CAFs biology are pointing to CAFs-secreted factors as druggable targets and companion tools for cancer diagnosis and prognosis. Especially, extensive research conducted in the recent years has underscored the potential of several cytokines as actionable biomarkers that are currently evaluated in the clinical setting. In this review, we explore the current understanding of CAFs secretome determinants and functions to discuss their clinical implication in oncology.

Matèries

Càncer, Tractament adjuvant del càncer, Metàstasi

Matèries (anglès)

Cancer, Adjuvant treatment of cancer, Metastasis

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

LINARES, Jenniffer, et al. Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy. Frontiers in Cell and Developmental Biology. 2021. Vol. 8. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/174366

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