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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222273
Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice
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Objective: The adaptive response to different models of regular exercise involves complex tissue crosstalk. Our aim was to explore the involvement of extracellular vesicle (EV) microRNAs (miRNAs) in this process, the secretory role of skeletal muscle and its functional metabolic interaction with the liver. Methods: Plasma EV miRNAs obtained from mice after 4-weeks of endurance or resistance training were sequenced. Subsequent experiments using trained genetically modified mouse models and in vitro approaches involving knock-down and electrostimulated cells, were conducted. Results: Resistance training increased the expression of a group of 11 miRNAs functionally divided into two clusters. Among them, miR-29a-3p emerges as a molecular mediator released in EVs by skeletal muscle, with a relevant role in adaptation to endurance training, by contributing to modulate the expression and secretion of other miRNAs associated with training and regulating processes related to substrate availability, transport, and metabolic use in skeletal muscle and liver. Conclusions: Our study suggests that miR-29a-3p is a training-induced molecular mediator in the response and adaptation to resistance training, possibly due to its regulatory role in energy metabolism in skeletal muscle in response to exercise. (c) 2025 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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PINTO HERNÁNDEZ, Paola, FERNÁNDEZ SANJURJO, Manuel, PAGET, Daan, CARAVIA, Xurde m., ROIZ VALLE, David, CASTILLA SILGADO, Juan, DIEZ ROBLES, Sergio, COTO VILCAPOMA, Almudena, FERNÁNDEZ VIVERO, David, GAMA PÉREZ, Pau, GARCÍA ROVES, Pablo miguel, LÓPEZ OTIN, Carlos, ZIERATH, Juleen r., KROOK, Anna, FERNÁNDEZ GARCÍA, Benjamin, TOMÁS ZAPICO, Cristina, IGLESIAS GUTIERREZ, Eduardo. Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice. _Molecular Metabolism_. 2025. Vol. 98, núm. 102173. [consulta: 26 de febrer de 2026]. ISSN: 2212-8778. [Disponible a: https://hdl.handle.net/2445/222273]