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gruzieva2016_2203.pdf (424.42 KB)

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2016-07-22

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Domini públic / Public domain
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/101564

Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure

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http://dx.doi.org/10.1289/EHP36

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BACKGROUND: Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation. OBJECTIVES: We investigated associations between exposure to air pollution, using nitrogen dioxide (NO2) as marker, and epigenome-wide cord blood DNA methylation. METHODS: We meta-analyzed the associations between NO2 exposure at residential addresses during pregnancy and cord blood DNA methylation (Illumina 450K) in four European and North-American studies (n=1,508) with subsequent look-up analyses in children aged 4 (n=733) and 8 (n=786) years. Additionally, we applied a literature-based candidate approach for antioxidant and anti-inflammatory genes. To assess influence of exposure at the transcriptomics level, we related mRNA expression in blood cells to NO2 exposure in 4- (n=111) and 16-year-olds (n=239). RESULTS: We found epigenome-wide significant associations (false discovery rate (FDR) p<0.05) between maternal NO2 exposure during pregnancy and DNA methylation in newborns for 3 CpG sites in mitochondria-related genes: cg12283362 (LONP1), cg24172570 (3.8 kbp upstream of HIBADH), and cg08973675 (SLC25A28). The associations with cg08973675 methylation were also significant in the older children. Further analysis of antioxidant and anti-inflammatory genes revealed differentially methylated CpGs in CAT and TPO in newborns (FDR p<0.05). NO2 exposure at the time of biosampling in childhood had significant impact on CAT and TPO expression. CONCLUSIONS: NO2 exposure during pregnancy was associated with differential offspring DNA methylation in mitochondria-related genes. Exposure to NO2 was also linked to differential methylation as well as expression of genes involved in antioxidant defense pathways.

Matèries

Contaminació, Medicina prenatal

Matèries (anglès)

Pollution, Prenatal medicine

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Articles publicats en revistes (ISGlobal)
<b>Publicacions de projectes de recerca finançats per la UE</b>

Citació

GRUZIEVA, Olena, XU, Cheng-jian, BRETON, Carrie v., ANNESI-MAESANO, Isabella, ANTÓ I BOQUÉ, Josep maria, AUFFRAY, Charles, BALLEREAU, Stephane, BELLANDER, Tom, BOUSQUET, Jean, BUSTAMANTE PINEDA, Mariona, CHARLES, Marie-aline, KLUIZENAAR, Yvonne de, DEKKER, Herman t. den, DUIJTS, Liesbeth, FELIX, Janine f., GEHRING, Ulrike, GUXENS, Mònica, JADDOE, Vincent w., JANKIPERSADSING, Soesma a., MERID, Simon kebede, KERE, Juha, KUMAR, Ashish, LEMONNIER, Nathanael, LEPEULE, Johanna, NYSTAD, Wenche, PAGE, Christian magnus, PANASEVICH, Sviatlana, POSTMA, Dirkje s., SLAMA, Rémy, SUNYER DEU, Jordi, SODERHALL, Cilla, YAO, Jin, LONDON, Stephanie j., PERSHAGEN, Göran, KOPPELMAN, Gerard h., MELÉN, Erik. Epigenome-Wide Meta-Analysis of Methylation in Children Related
                to Prenatal NO2 Air Pollution Exposure. _Environmental Health Perspectives_. 2016. [consulta: 25 de gener de 2026]. ISSN: 0091-6765. [Disponible a: https://hdl.handle.net/2445/101564]

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