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2017-08-01

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/191073

Chromium exposure and risk of cardiovascular disease in high cardiovascular risk subjects - nested case-control study in the prevention with mediterranean diet (PREDIMED) study

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https://doi.org/10.1253/circj.CJ-17-0032

Abstract

Background: Epidemiological data on chromium (Cr) exposure and the risk of cardiovascular disease (CVD) are still limited. Toenail Cr level (TCL) provides a time-integrated measure reflecting long-term Cr exposure. We measured TCL to assess the hypothesis that long-term Cr exposure was inversely associated with incident CVD in a population at high risk for CVD.Methods and Results: The associations between TCL and CVD were evaluated in a case-control study nested within the 'PREvencion con Dleta MEDiterranea' (PREDIMED) trial. We randomly selected 147 of the 288 patients diagnosed with CVD during follow-up and matched them on age and sex to 271 controls. Instrumental neutron activation analysis was used to assess TCL. In-person interviews, medical record reviews, and validated questionnaires were used to assess covariates. The fully adjusted OR for the highest vs. lowest quartile of toenail Cr was 0.54 (95% CI: 0.26-1.14; P-trend=0.189) for the nested case-control study. On stratification for diabetes mellitus (DM), OR was 1.37 (95% CI: 0.54-3.46; P-trend=0.364) for the DM group, and 0.25 (95% CI: 0.08-0.80; P-trend=0.030) for the non-DM group (P for interaction=0.078).Conclusions: The present findings, although not statistically significant, are consistent with previously reported inverse associations between TCL and CVD. These results, especially for non-DM patients, increase the limited epidemiological knowledge about the possible protective role of Cr against CVD.

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Malalties cardiovasculars, Diabetis, Dieta, Cuina mediterrània

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Cardiovascular diseases, Diabetes, Diet, Mediterranean cooking

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

GUTIERREZ BEDMAR, Mario, et al. Chromium exposure and risk of cardiovascular disease in high cardiovascular risk subjects - nested case-control study in the prevention with mediterranean diet (PREDIMED) study. Circulation Journal. 2017. Vol. 81, num. 8, pags. 1183-1190. ISSN 1346-9843. [consulted: 9 of June of 2026]. Available at: https://hdl.handle.net/2445/191073

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