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2017-08-01

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/191073

Chromium exposure and risk of cardiovascular disease in high cardiovascular risk subjects - nested case-control study in the prevention with mediterranean diet (PREDIMED) study

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https://doi.org/10.1253/circj.CJ-17-0032

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Background: Epidemiological data on chromium (Cr) exposure and the risk of cardiovascular disease (CVD) are still limited. Toenail Cr level (TCL) provides a time-integrated measure reflecting long-term Cr exposure. We measured TCL to assess the hypothesis that long-term Cr exposure was inversely associated with incident CVD in a population at high risk for CVD.Methods and Results: The associations between TCL and CVD were evaluated in a case-control study nested within the 'PREvencion con Dleta MEDiterranea' (PREDIMED) trial. We randomly selected 147 of the 288 patients diagnosed with CVD during follow-up and matched them on age and sex to 271 controls. Instrumental neutron activation analysis was used to assess TCL. In-person interviews, medical record reviews, and validated questionnaires were used to assess covariates. The fully adjusted OR for the highest vs. lowest quartile of toenail Cr was 0.54 (95% CI: 0.26-1.14; P-trend=0.189) for the nested case-control study. On stratification for diabetes mellitus (DM), OR was 1.37 (95% CI: 0.54-3.46; P-trend=0.364) for the DM group, and 0.25 (95% CI: 0.08-0.80; P-trend=0.030) for the non-DM group (P for interaction=0.078).Conclusions: The present findings, although not statistically significant, are consistent with previously reported inverse associations between TCL and CVD. These results, especially for non-DM patients, increase the limited epidemiological knowledge about the possible protective role of Cr against CVD.

Matèries

Malalties cardiovasculars, Diabetis, Dieta, Cuina mediterrània

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Cardiovascular diseases, Diabetes, Diet, Mediterranean cooking

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

GUTIERREZ BEDMAR, Mario, MARTÍNEZ-GONZÁLEZ, Miguel ángel, MUÑOZ BRAVO, Carlos, RUIZ CANELA, Miguel, MARISCAL, Alberto, SALAS SALVADÓ, Jordi, ESTRUCH RIBA, Ramon, CORELLA PIQUER, Dolores, AROS, Fernando, FITÓ COLOMER, Montserrat, LAPETRA, José, SERRA MAJEM, Lluís, PINTÓ SALA, Xavier, ALONSO GÓMEZ, Ángel m., PORTOLES, Olga, FIOL SALA, Miguel, BULLÓ, Mònica, CASTAÑER, Olga, ROS RAHOLA, Emilio, GOMEZ-GRACIA, Enrique. Chromium exposure and risk of cardiovascular disease in high cardiovascular risk subjects - nested case-control study in the prevention with mediterranean diet (PREDIMED) study. _Circulation Journal_. 2017. Vol. 81, núm. 8, pàgs. 1183-1190. [consulta: 23 de gener de 2026]. ISSN: 1346-9843. [Disponible a: https://hdl.handle.net/2445/191073]

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