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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222078
Efficacy of cognitive rehabilitation in cognition and brain networks: a randomised clinical trial in patients with multiple sclerosis
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This study evaluated the efficacy of the computerised Guttmann, NeuroPersonalTrainer (R)(GNPT) cognitive rehabilitation (CR) and characterised the induced changes in cerebral networks in patients with multiple sclerosis (MS). This multicentre, double-blind, randomised clinical trial compared upward intensity training (active treatment) to low-intensity static training (static treatment). Cognition was assessed using the Brief Repeatable battery before and after 12 weeks of training and at 10-months follow-up, and patients were classified as having a mild or severe cognitive impairment (CI). Brain MRI pre-and post-CR were analysed using an advanced tractography algorithm, based on multishell diffusion MRI, to obtain node-based graph metrics (local efficiency and strength) from microscopic fractional anisotropy. Seventy MS patients completed the study (age 48.9 +/- 8.8, disease duration 16.8 +/- 9.0 years); active treatment: 36, static treatment: 34. Verbal memory improved significantly post-CR in both groups (55 % active; 34 % static treatment), accompanied by increases in local efficiency and strength in multimodal regions. At follow-up, verbal memory declined in both groups but remained above the pre-CR assessment (-25 % and-17 %, respectively). Patients with severe-CI (n = 36) showed improvement only with active treatment, while those with mild-CI (n = 34) improved regardless of intensity treatment. Network changes were more pronounced in patients in active treatment and in those with severe-CI. Quality of life did not change at post-CR, and cognitive improvement was influenced by cognitive reserve (p = 0.011). In MS, GNPT temporarily improves verbal memory and increases network connectivity, reinforcing the CR as a valuable tool for enhancing cognitive skills and promoting neuronal plasticity.
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LÓPEZ SOLEY, Elisabet, et al. Efficacy of cognitive rehabilitation in cognition and brain networks: a randomised clinical trial in patients with multiple sclerosis. NeuroImage Clinical. 2025. Vol. 46, num. 103775. ISSN 2213-1582. [consulted: 6 of June of 2026]. Available at: https://hdl.handle.net/2445/222078