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Respiratory chain dysfunction associated with multiple mitochondrial DNA deletions in antiretroviral therapy-related lipodystrophy.

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Highly-active antiretroviral therapy (HAART) can induce a characteristic lipodystrophy syndrome characterized by peripheral fat wasting and central adiposity, usually associated with hyperlipidaemia and insulin resistance [1,2]. Indirect data have led some authors to propose that mitochondrial dysfunction could play a role in this syndrome [3,4].To date, as recently outlined by Kakuda et al. [5] in this journal, HIV-infected patients developing lipodystrophy have not been studied for mitochondrial changes or respiratory chain capacity...

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MIRÓ I ANDREU, Òscar, GÓMEZ, Montserrat, PEDROL, Enric, CARDELLACH, Francesc, NUNES MARTÍNEZ, Virginia, CASADEMONT I POU, Jordi. Respiratory chain dysfunction associated with multiple mitochondrial DNA deletions in antiretroviral therapy-related lipodystrophy.. _AIDS_. 2000. Vol. 14, núm. 12, pàgs. 1855-1857. [consulta: 30 de gener de 2026]. ISSN: 0269-9370. [Disponible a: https://hdl.handle.net/2445/41644]

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