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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/198562
Specific biomarker comparison in current smokers, e-cigarette users, and non-smokers
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Introduction: This study aims to address the existing gap in the literature, while adding evidence, by comparing tobacco-specific biomarkers (cotinine and nitrosamines: NNK, NNAL, NNN), and other biomarkers of e-cigarette use (humectants: glycerol, 1,2-PD, 1,3-PD) according to five study groups.
Methods: A pooling analysis including two different studies was conducted. In both analyses, we took saliva samples from smokers (n = 409) and non-smokers (n = 154), dual tobacco and e-cig users (n = 92), exclusive e-cig user with nicotine (n = 158), and exclusive e-cig users without nicotine (n = 38). We analyzed and compared the geometric means (GM) and geometric standard deviations (GSD) of the concentration of tobacco-specific biomarkers, and e-cigarette biomarkers among groups. We used log-linear models adjusted for sex and age to model the change percentage and their 95% confidence intervals.
Results: Cotinine was significantly higher in nicotine consumers and in e-cigarette users without nicotine when compared to non-smokers. TSNAs were generally significantly lower in non-smokers and higher in nicotine consumers. NNN and NNAL were lower in e-cigarette users with nicotine comparted to smokers, and NNN was higher in e-cigarette users without nicotine when compared to non-smokers. No differences were found in humectant biomarkers between e-cigarette groups.
Conclusions: Although there was a reduction in TSNAs in e-cigarette exclusive users compared to smokers, and a reduction of cotinine concentrations in e-cigarette exclusive users without nicotine compared to smokers, there are still high levels of these biomarkers when compared to non-smokers, which may be a clue towards the harmful effect of e-cigarettes.
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MELERO OLLONARTE, Juan luis, LIDÓN MOYANO, Cristina, PEREZ ORTUÑO, Raúl, FU BALBOA, Marcela, BALLBÈ I GIBERNAU, Montse, MARTÍN SÁNCHEZ, Juan carlos, GONZÁLEZ BARRÓN, Adrián, CARTANYÀ HUESO, Àurea, PASCUAL, José antonio, FERNÁNDEZ MUÑOZ, Esteve, MARTÍNEZ SÁNCHEZ, Jose m.. Specific biomarker comparison in current smokers, e-cigarette users, and non-smokers. _Addictive Behaviors_. 2023. Vol. 140, núm. 107616. [consulta: 25 de gener de 2026]. ISSN: 1873-6327. [Disponible a: https://hdl.handle.net/2445/198562]