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Melero-Ollonarte.pdf (1.36 MB)

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2023-01-19

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cc by-nc-nd (c) Elsevier, 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/198562

Specific biomarker comparison in current smokers, e-cigarette users, and non-smokers

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Recurs relacionat

https://doi.org/10.1016/j.addbeh.2023.107616

Resum

Introduction: This study aims to address the existing gap in the literature, while adding evidence, by comparing tobacco-specific biomarkers (cotinine and nitrosamines: NNK, NNAL, NNN), and other biomarkers of e-cigarette use (humectants: glycerol, 1,2-PD, 1,3-PD) according to five study groups. Methods: A pooling analysis including two different studies was conducted. In both analyses, we took saliva samples from smokers (n = 409) and non-smokers (n = 154), dual tobacco and e-cig users (n = 92), exclusive e-cig user with nicotine (n = 158), and exclusive e-cig users without nicotine (n = 38). We analyzed and compared the geometric means (GM) and geometric standard deviations (GSD) of the concentration of tobacco-specific biomarkers, and e-cigarette biomarkers among groups. We used log-linear models adjusted for sex and age to model the change percentage and their 95% confidence intervals. Results: Cotinine was significantly higher in nicotine consumers and in e-cigarette users without nicotine when compared to non-smokers. TSNAs were generally significantly lower in non-smokers and higher in nicotine consumers. NNN and NNAL were lower in e-cigarette users with nicotine comparted to smokers, and NNN was higher in e-cigarette users without nicotine when compared to non-smokers. No differences were found in humectant biomarkers between e-cigarette groups. Conclusions: Although there was a reduction in TSNAs in e-cigarette exclusive users compared to smokers, and a reduction of cotinine concentrations in e-cigarette exclusive users without nicotine compared to smokers, there are still high levels of these biomarkers when compared to non-smokers, which may be a clue towards the harmful effect of e-cigarettes.

Matèries

Cigarretes electròniques, Marcadors bioquímics, Tabac, Fumadors

Matèries (anglès)

Electronic cigarettes, Biochemical markers, Tobacco, Cigarette smokers

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

MELERO OLLONARTE, Juan Luis, et al. Specific biomarker comparison in current smokers, e-cigarette users, and non-smokers. Addictive Behaviors. 2023. Vol. 140, num. 107616. ISSN 1873-6327. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/198562

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