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2008-08-28

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cc-by-nc (c) Castellote Alonso, José et al., 2008
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/127550

Serious drug-induced liver disease secondary to ezetimibe

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https://doi.org/10.3748/wjg.14.5098

Abstract

Ezetimibe is the first member of a new family of lipid-lowering drugs that inhibits uptake of dietary and biliary cholesterol. It was approved by the FDA in 2002 for hypercholesterolemia alone or in combination with statins. Its use has been spreading over the last years. Ezetimibe was considered a safe drug. We report a case of a woman who developed a serious hepatocellular drug-induced liver disease after 4 mo therapy with 10 mg daily of ezetimibe. After withdrawal of the drug, the patient recovered slowly. Ezetimibe may produce serious toxic hepatitis and prompt withdrawal is mandatory in case of a significant abnormality in liver testing after beginning or during treatment with ezetimibe.

Subject

Hepatitis, Efectes secundaris dels medicaments, Malalties del fetge

Subject (English)

Hepatitis, Drug side effects, Liver diseases

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

CASTELLOTE ALONSO, José, et al. Serious drug-induced liver disease secondary to ezetimibe. World Journal of Gastroenterology. 2008. Vol. 14, num. 32, pags. 5098-5099. ISSN 1007-9327. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/127550

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