Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126774
Single Nucleotide Polymorphisms Of Matrix Metalloproteinase 9 (MMP9) And Tumor Protein 73 (TP73) Interact With Epstein-Barr Virus In Chronic Lymphocytic Leukemia: Results From The European Case-Control Study EpiLymph
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Using EpiLymph case-control data, we found that chronic lymphocytic leukemia patients were more likely to have abnormal reactive serological patterns to Epstein Barr virus than controls. Here, we aimed to assess whether this association is modified by genetic variants. We examined 1,305 Single Nucleotide Polymorphisms from 300 selected genes related to various pathways in 240 cases and 513 controls from five European centers. In a recessive model, patients positive to aberrant antibody pattern and homozygous for rare genotypes in rs8113877T > G or rs17576A > G of the MMP9 gene were at highest risk of chronic lymphocytic leukemia. In a dominant model, TP73 showed the highest risk in patients positive to aberrant antibody pattern and homozygous for the wild-type genotype in rs1885859G > C or rs3765701A > T. All interactions were additive and no main effect was observed. The strong interactions observed may be indicative of a specific pathway in cancer genesis. Confirmation of these results is warranted.
Matèries (anglès)
Citació
Citació
CASABONNE, Delphine, REINA, Oscar, BENAVENTE, Yolanda, BECKER, Nikolaus, MAYNADIÉ, Marc, FORETOVÁ, Lenka, COCCO, Pierluigi, GONZÁLEZ NEIRA, Anna, NIETERS, Alexandra, BOFFETTA, Paolo, MIDDELDORP, Jaap m., SANJOSÉ LLONGUERAS, Silvia de. Single Nucleotide Polymorphisms Of Matrix Metalloproteinase 9 (MMP9) And Tumor Protein 73 (TP73) Interact With Epstein-Barr Virus In Chronic Lymphocytic Leukemia: Results From The European Case-Control Study EpiLymph. _Haematologica_. 2011. Vol. 96, núm. 2, pàgs. 323-327. [consulta: 23 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/126774]