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2018-11-26

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/127015

Direct Asymmetric Hydrogenation of N-Methyl and N-Alkyl Imines with an Ir(III)H Catalyst

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https://doi.org/10.1021/jacs.8b11547

Abstract

A novel cationic [IrH(THF)(P,N)(imine)] [BArF] catalyst contg. a P-stereogenic MaxPHOX ligand is described for the direct asym. hydrogenation of N-Me and N-alkyl imines. This is the first catalytic system to attain high enantioselectivity (up to 94% ee) in this type of transformation. The labile THF ligand allows for effective activation and reactivity, even at low temps. D. functional theory calcns. allowed the rationalization of the stereochem. course of the reaction.

Subject

Catàlisi asimètrica, Lligands, Hidrogenació

Subject (English)

Enantioselective catalysis, Ligands, Hydrogenation

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Articles publicats en revistes (Química Inorgànica i Orgànica)

Citation

SALOMÓ I PRAT, Ernest, et al. Direct Asymmetric Hydrogenation of N-Methyl and N-Alkyl Imines with an Ir(III)H Catalyst. Journal of the American Chemical Society. 2018. Vol. 140, num. 16967-16970. ISSN 0002-7863. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/127015

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