Fitxers

727175.pdf (563.44 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2022-10-26

Llicència de publicació

cc-by (c) Domínguez López, Inés et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/193994

Relationship between estimated desaturase enzyme activity and metabolic syndrome in a longitudinal study

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.3389/fnut.2022.991277

Resum

Desaturase enzyme activities (DEA) are associated with several metabolic diseases. The aim of the present study was to assess the relationship between estimated plasma DEA and the metabolic syndrome (MetS), as well as their relationship with individual components of the MetS. We conducted a longitudinal study of 148 participants recruited at random from the PREDIMED trial (Hospital Clinic site). At baseline and after 1 year of follow-up, DEA were estimated from product/precursor ratios of individual plasma fatty acids. Logistic regressions were used to assess the relationship of estimated DEA MetS, adjusted for potential cofounders. Estimated Δ5 desaturase (D5D) activity was associated with lower risk of MetS, whereas stearoyl-CoA (SCD)-16 and SCD-18 were negatively associated with MetS status. SCD-16, SCD-18, and Δ6 desaturase (D6D) were positively associated with triglycerides, SCD-18 was inversely associated with HDL-cholesterol. Estimated D6D activity was found to be associated with increases in diastolic blood pressure. In contrast, D5D was negatively associated with triglycerides, diastolic blood pressure and waist circumference. The present longitudinal study suggests that estimated SCD-16, SCD-18, and D6D have a negative impact in MetS and its components, whereas D5D may have beneficial effects for metabolic health.

Matèries

Síndrome metabòlica, Enzims

Matèries (anglès)

Metabolic syndrome, Enzymes

Citació

Col·leccions

Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

DOMÍNGUEZ LÓPEZ, Inés, et al. Relationship between estimated desaturase enzyme activity and metabolic syndrome in a longitudinal study. Frontiers In Nutrition. 2022. Vol. 9. ISSN 2296-861X. [consulted: 9 of September of 2026]. Available at: https://hdl.handle.net/2445/193994

Exportar metadades

JSON - METS

Compartir registre