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2007-06-01

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cc by (c) Pérez de los Cobos Peris et al., 2007
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126407

Allelic and genotypic associations of DRD2 Taq I A polymorphism with heroin dependence in Spanish subjects: a case control study

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Recurs relacionat

https://doi.org/10.1186/1744-9081-3-25

Resum

Background: Conflicting associations with heroin dependence have been found involving the A1 allele of dopamine D2 receptor gene ( DRD2) TaqI A polymorphism. Methods: We compared two samples of unrelated Spanish individuals, all of European origin: 281 methadone-maintained heroin-dependent patients ( 207 males and 74 females) who frequently used non-opioid substances, and 145 control subjects ( 98 males and 47 females). Results: The A1-A1 genotype was detected in 7.1% of patients and 1.4% of controls ( P = 0.011, odds ratio = 5.48, 95% CI 1.26-23.78). Although the A1 allele was not associated with heroin dependence in the entire sample, the frequency of A1 allele was higher in male patients than in male controls ( 24.4% vs. 16.3%, P = 0.024, odds ratio = 1.65, 95% CI 1.07-2.57). A logistic regression analysis showed an interaction between DRD2 alleles and gender ( odds ratio = 1.77, 95% CI 1.15-2.70). Conclusion: Our results indicate that, in Spanish individuals, genotypes of the DRD2 TaqI A polymorphism contribute to variations in the risk of heroin dependence, while single alleles contribute only in males.

Matèries

Heroïna, Metadona

Matèries (anglès)

Heroin, Methadone hydrochloride

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

PÉREZ DE LOS COBOS PERIS, José c., BAIGET BASTÚS, Montserrat, TRUJOLS I ALBET, Joan, SINOL, Nuria, VOLPINI BERTRÁN, Víctor, BANULS, Enrique, CALAFELL, Francesc, LUQUERO, Elena, RIO, Elisabeth del, ALVAREZ, Enric. Allelic and genotypic associations of DRD2 Taq I A polymorphism with heroin dependence in Spanish subjects: a case control study. _Behavioral and Brain Functions_. 2007. Vol. 3, núm. 25. [consulta: 24 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/126407]

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