Miniatura

Fitxers

s41467-021-23472-7.pdf (3.33 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2021-06-10

Llicència de publicació

cc by (c) Soret, Perrine et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/179151

A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1038/s41467-021-23472-7

Resum

There is currently no approved treatment for primary Sjögren's syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies is -in part- because of the heterogeneity in the clinical manifestation and pathophysiology of the disease. Finding common molecular signatures among patient subgroups could improve our understanding of disease etiology, and facilitate the development of targeted therapeutics. Here, we report, in a cross-sectional cohort, a molecular classification scheme for Sjögren's syndrome patients based on the multi-omic profiling of whole blood samples from a European cohort of over 300 patients, and a similar number of age and gender-matched healthy volunteers. Using transcriptomic, genomic, epigenetic, cytokine expression and flow cytometry data, combined with clinical parameters, we identify four groups of patients with distinct patterns of immune dysregulation. The biomarkers we identify can be used by machine learning classifiers to sort future patients into subgroups, allowing the re-evaluation of response to treatments in clinical trials.

Matèries

Malalties autoimmunitàries, Assaigs clínics, Marcadors bioquímics, Epigenètica

Matèries (anglès)

Autoimmune diseases, Clinical trials, Biochemical markers, Epigenetics

Citació

Col·leccions

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

SORET, Perrine, LE DANTEC, Christelle, DESVAUX, Emiko, FOULQUIER, Nathan, CHASSAGNOL, Bastien, HUBERT, Sandra, JAMIN, Christophe, BARTUREN, Guillermo, DESACHY, Guillaume, DEVAUCHELLE PENSEC, Valérie, BOUDJENIBA, Cheïma, CORNEC, Divi, SARAUX, Alain, JOUSSE JOULIN, Sandrine, BARBARROJA, Nuria, RODRÍGUEZ PINTÓ, Ignasi, DE LANGHE, Ellen, BERETTA, Lorenzo, CHIZZOLINI, Carlo, KOVÁCS, László, WITTE, Torsten, PRECISESADS Clinical Consortium, PRECISESADS Flow Cytometry Consortium, BETTACCHIOLI, Eléonore, BUTTGEREIT, Anne, MAKOWSKA, Zuzanna, LESCHE, Ralf, BORGHI, Maria orietta, MARTIN, Javier, COURTADE GAIANI, Sophie, XUEREB, Laura, GUEDJ, Mickaël, MOINGEON, Philippe, ALARCÓN RIQUELME, Marta, LAIGLE, Laurence, PERS, Jacques-olivier. A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome. _Nature Communications_. 2021. Vol. 12, núm. 3523. [consulta: 25 de febrer de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/179151]

Exportar metadades

JSON - METS

Compartir registre