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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/181130
Prognosis impact of diabetes in elderly women and men with non-ST elevation acute coronary syndrome
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Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged ≥70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 ± 5.75 vs. 78.45 ± 5.43 years, p < 0.001) and more often had a history of hypertension (77% vs. 83.1%, p < 0.01). Anemia and chronic kidney disease were both more common in women. On the other hand, they less frequently had a prior history of arteriosclerotic cardiovascular disease or comorbidities such as peripheral artery disease and chronic pulmonary disease. Women showed a worse clinical profile on admission, though an invasive approach and in-hospital revascularization were both more often performed in men (p < 0.001). At a one-year follow-up, 1090 patients (15%) had died, without a difference between sexes. Male sex was an independent predictor of mortality (HR = 1.15, 95% CI 1.01 to 1.32, p = 0.035), and there was a significant interaction between sex and DM (p = 0.002). DM was strongly associated with mortality in women (HR: 1.45, 95% CI = 1.18-1.78; p < 0.001), but not in men (HR: 0.98, 95% CI = 0.84-1.14; p = 0.787). In conclusion, DM is associated with mortality in older women with NSTEACS, but not in men.
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DÍEZ-VILLANUEVA, Pablo, GARCÍA ACUÑA, José maría, RAPOSEIRAS ROUBÍN, Sergio, BARRABÉS, José a., CORDERO, Alberto, MARTÍNEZ-SELLÉS, Manuel, BARDAJÍ, Alfredo, MARÍN, Francisco, RUIZ-NODAR, Juan m., VICENTE-IBARRA, Nuria, ALONSO SALINAS, Gonzalo luis, CID-ALVÁREZ, Belén, ABU-ASSI, Emad, FORMIGA PÉREZ, Francesc, NÚÑEZ, Julio, NÚÑEZ, Eduardo, SANCHIS FORÉS, Juan, ARIZA SOLÉ, Albert. Prognosis impact of diabetes in elderly women and men with non-ST elevation acute coronary syndrome. _Journal of Clinical Medicine_. 2021. Vol. 10, núm. 19, pàgs. 4403. [consulta: 20 de gener de 2026]. ISSN: 2077-0383. [Disponible a: https://hdl.handle.net/2445/181130]