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2021-10-22

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/188749

Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation

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https://doi.org/10.1021/acs.chemrev.1c00496

Abstract

Chiral amines are key structural motifs present in a wide variety of natural products, drugs, and other biologically active compounds. During the last decade, significant advances have been made with respect to the enantioselective synthesis of chiral amines, many of them based on catalytic asymmetric hydrogenation (AH). The present review covers the use of AH in the synthesis of chiral amines bearing a stereogenic center either in α, β or γ position with respect to the nitrogen atom, reported from 2010 to 2020. Therefore, we provide an overview of the recent advances in the AH of imines, enamides, enamines, allyl amines and N-heteroaromatic compounds.

Subject

Catàlisi, Hidrogenació, Amines

Subject (English)

Catalysis, Hydrogenation, Amines

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Articles publicats en revistes (Química Inorgànica i Orgànica)

Citation

CABRÉ MONTESINOS, Albert, VERDAGUER I ESPAULELLA, Xavier and RIERA I ESCALÉ, Antoni. Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation. Chemical Reviews. 2021. Vol. 122, num. 1, pags. 269-339. ISSN 0009-2665. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/188749

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