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2015-09

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cc-by-nc-nd (c) Elsevier B.V., 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/130565

Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma

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https://doi.org/10.1016/j.ejca.2015.05.023

Resum

Introduction: In patients with primary cutaneous melanoma, there is generally a delay between excisional biopsy of the primary tumour and sentinel-node biopsy. The objective of this study is to analyse the prognostic implications of this delay. Patients and method: This was an observational, retrospective, cohort study in four tertiary referral hospitals. A total of 1963 patients were included. The factor of interest was the interval between the date of the excisional biopsy of the primary melanoma and the date of the sentinel-node biopsy (delay time) in the prognosis. The primary outcome was melanoma-specific survival and disease-free survival. Results: A delay time of 40 days or less (hazard ratio (HR), 1.7; confidence interval (CI), 1.2-2.5) increased Breslow thickness (Breslow ⩾2 mm, HR, >3.7; CI, 1.4-10.7), ulceration (HR, 1.6; CI, 1.1-2.3), sentinel-node metastasis (HR, 2.9; CI, 1.9-4.2), and primary melanoma localised in the head or neck were independently associated with worse melanoma-specific survival (all P < 0.03). The stratified analysis showed that the effect of delay time was at the expense of the patients with a negative sentinel-node biopsy and without regression. Conclusion: Early sentinel-node biopsy is associated with worse survival in patients with cutaneous melanoma.

Matèries

Melanoma, Càncer de pell, Nodes limfàtics

Matèries (anglès)

Melanoma, Skin cancer, Lymph nodes

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

TEJERA VAQUERIZO, Antonio, NAGORE, Eduardo, PUIG I SARDÀ, Susana, ROBERT, Caroline, SAIAG, Philippe, MARTÍN-CUEVAS, Paula, GALLEGO, Elena, HERRERA ACOSTA, Enrique, AGUILERA, José, MALVEHY, J. (josep), CARRERA ÁLVAREZ, Cristina, CAVALCANTI, Andrea, RULL, Ramón, VILALTA SOLSONA, Antonio, LANNOY, Emilie, BOUTROS, Celine, BENANNOUNE, Naima, TOMASIC, Gorana, AEGERTE, Philippe, VIDAL I SICART, Sergi, PALOU, Josep, ALÓS I HERNÁNDEZ, Llúcia, REQUENA, Celia, TRAVES, Víctor, PLA, Ángel, BOLUMAR, Isidro, SORIANO, Virtudes, GUILLÉN, Carlos, HERRERA CEBALLOS, Enrique. Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma. _European Journal of Cancer_. 2015. Vol. 51, núm. 13, pàgs. 1780-1793. [consulta: 21 de gener de 2026]. ISSN: 0959-8049. [Disponible a: https://hdl.handle.net/2445/130565]

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