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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/125712
Effects of an 18-week exercise programme started early during breast cancer treatment: a randomised controlled trial
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Background: Exercise started shortly after breast cancer diagnosis might prevent or diminish fatigue complaints. The Physical Activity during Cancer Treatment (PACT) study was designed to primarily examine the effects of an 18-week exercise intervention, offered in the daily clinical practice setting and starting within 6 weeks after diagnosis, on preventing an increase in fatigue. Methods: This multi-centre controlled trial randomly assigned 204 breast cancer patients to usual care (n = 102) or supervised aerobic and resistance exercise (n = 102). By design, all patients received chemotherapy between baseline and 18 weeks. Fatigue (i.e., primary outcome at 18 weeks), quality of life, anxiety, depression, and physical fitness were measured at 18 and 36 weeks. Results: Intention-to-treat mixed linear model analyses showed that physical fatigue increased significantly less during cancer treatment in the intervention group compared to control (mean between-group differences at 18 weeks: -1.3; 95 % CI -2.5 to -0.1; effect size -0.30). Results for general fatigue were comparable but did not reach statistical significance (-1.0, 95% CI -2.1; 0.1; effect size -0.23). At 18 weeks, submaximal cardiorespiratory fitness and several muscle strength tests (leg extension and flexion) were significantly higher in the intervention group compared to control, whereas peak oxygen uptake did not differ between groups. At 36 weeks these differences were no longer statistically significant. Quality of life outcomes favoured the exercise group but were not significantly different between groups. Conclusions: A supervised 18-week exercise programme offered early in routine care during adjuvant breast cancer treatment showed positive effects on physical fatigue, submaximal cardiorespiratory fitness, and muscle strength. Exercise early during treatment of breast cancer can be recommended. At 36 weeks, these effects were no longer statistically significant. This might have been caused by the control participants' high physical activity levels during follow-up.
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TRAVIER, Noémie, VELTHUIS, Miranda j., STEINS BISSCHOP, Charlotte n., BUIJS, Bram van den, MONNINKHOF, Evelyn m., BACKX, Frank, LOS, Maartje, ERDKAMP, Frans, BLOEMENDAL, Haiko j., RODENHUIS, Carla, ROOS, Marnix a.j. de, VERHAAR, Marlies, BOKKEL HUININK, Daan ten, WALL, Elsken van der, PEETERS, Petra h. m., MAY, Anne m.. Effects of an 18-week exercise programme started early during breast cancer treatment: a randomised controlled trial. _BMC Medicine_. 2015. Vol. 13, núm. 121. [consulta: 23 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/125712]