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2021-01-29

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cc by-nc (c) Anton Pampols et al., 2021
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/177731

Immunosuppression minimization in kidney transplant recipients hospitalized for COVID-19

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https://doi.org/10.1093/ckj/sfab025

Abstract

Background. Immunosuppressed patients such as kidney transplant recipients (KTs) have increased mortality risk in the setting of coronavirus disease 2019 (COVID-19). The role and management of chronic immunosuppressive therapies during COVID-19 must be characterized. Methods. Herein, we report the follow-up of a cohort of 47 KTs admitted at two Spanish Kidney Transplant Units, who survived COVID-19. The impact of the management of immunosuppression during COVID-19 on graft function and immunologic events was evaluated. Results. At least one immunosuppressive agent was withdrawn in 83% of patients, with antimetabolites being the most frequent. Steroids were generally not stopped and the dose was even increased in 15% of patients as part of the treatment of COVID-19. Although immunosuppressive drugs were suspended during a median time of 17 days, no rejection episodes or de novo donorspecific antibodies were observed up to 3 months after discharge, and no significant changes occurred in calculated panel reactive antibodies. Acute graft dysfunction was common (55%) and the severity was related to tacrolimus trough levels, which were higher in patients receiving antivirals. At the end of follow-up, all patients recovered baseline kidney function. Conclusions. Our observational study suggests that immunosuppression in KTs hospitalized due to COVID-19 could be safely minimized.

Subject

Immunosupressors, COVID-19, Trasplantament renal

Subject (English)

Immunosupressive agents, COVID-19, Kidney transplantation

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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ANTON PAMPOLS, Paula, et al. Immunosuppression minimization in kidney transplant recipients hospitalized for COVID-19. Clinical Kidney Journal. 2021. Vol. 14, num. 4, pags. 1229-1235. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/177731

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