Miniatura

Fitxers

713303.pdf (1.38 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2021-05-15

Llicència de publicació

cc-by (c) Santos García, Diego et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/180192

Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1155/2021/8871549

Resum

Introduction: In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. Materials and methods: Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0-20; B: NMSS = 21-40; C: NMSS = 41-70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results: A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p < 0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p < 0.005; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; p < 0.0001). Conclusion: The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the HΨ Patients with a lower H&Y stage may be more affected if they have a greater NMS burden.

Matèries

Malaltia de Parkinson

Matèries (anglès)

Parkinson's disease

Citació

Col·leccions

Articles publicats en revistes (Medicina)

Citació

SANTOS GARCÍA, Diego, DE DEUS FONTICOBA, Teresa, PAZ GONZÁLEZ, Jose, CORES BARTOLOMÉ, Carlos, VALDÉS AYMERICH, Lorena, MUÑOZ ENRÍQUEZ, J. g., SUÁREZ, Ester, JESÚS, Silvia, AGUILAR, Miquel, PASTOR, Pau, PLANELLAS, Lluís, COSGAYA, Marina, GARCÍA CALDENTEY, Juan, CABALLOL, Núria, LEGARDA, Ines, HERNÁNDEZ VARA, Jorge, CABO, Iria, LÓPEZ MANZANARES, Lydia, GONZÁLEZ ARAMBURU, Isabel, ÁVILA RIVERA, Maria asunción, CATALÁN, María josé, NOGUEIRA, Víctor, PUENTE, Víctor, GARCÍA MORENO, Jose manuel, BORRUÉ, Carmen, SOLANO VILA, Berta, ÁLVAREZ SAUCO, Maria, VELA, Lydia, ESCALANTE ARROYO, Sonia, CUBO, Esther, CARRILLO PADILLA, Francisco, MARTÍNEZ CASTRILLO, Juan, SÁNCHEZ ALONSO, Pilar, ALONSO LOSADA, Maria gema, LÓPEZ ARIZTEGUI, Nuria, GASTÓN, Itziar, KULISEVSKY, Jaime, BLÁZQUEZ ESTRADA, M., SEIJO MARTÍNEZ, Manuel, RÚIZ MARTÍNEZ, Javier. Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life.. _Parkinson's Disease_. 2021. [consulta: 24 de gener de 2026]. ISSN: 2042-0080. [Disponible a: https://hdl.handle.net/2445/180192]

Exportar metadades

JSON - METS

Compartir registre