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jcm-10-00709-v2.pdf (839.92 KB)

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2021-02-11

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cc by (c) Troncoso Mariño et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/176033

Medication-Related Problems in Older People with Multimorbidity in Catalonia: A Real-World Data Study with 5 Years’ Follow-Up

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https://doi.org/10.3390/jcm10040709

Resum

Aging, multimorbidity, and polypharmacy are associated with medication-related problems (MRPs). This study aimed to assess the association that multimorbidity and mortality have with MRPs in older people over time. We followed multimorbid, older (65-99 years) people in Catalonia from 2012 to 2016, using longitudinal data and Cox models to estimate adjusted hazard ratios (HR). We reviewed electronic health records to collect explanatory variables and MRPs (duplicate therapy, drug-drug interactions, potentially inappropriate medications (PIM), and contraindicated drugs in chronic kidney disease (CKD) or liver disease). There were 723,016 people (median age: 74 years; 58.9% women) who completed follow-up. We observed a significant (p < 0.001) increase in the proportion with at least one MRP (2012: 66.9% to 2016: 75.5%); contraindicated drugs in CKD (11.1 to 18.5%) and liver disease (3.9 to 5.3%); and PIMs (62.5 to 71.1%), especially drugs increasing fall risk (67.5%). People with ≥10 diseases had more MRPs (in 2016: PIMs, 89.6%; contraindicated drugs in CKD, 34.4%; and in liver disease, 9.3%). All MRPs were independently associated with mortality, from duplicate therapy (HR 1.06; 95% confidence interval (CI) 1.04-1.08) to interactions (HR 1.60; 95% CI 1.54-1.66). Ensuring safe pharmacological treatment in elderly, multimorbid patient remains a challenge for healthcare systems.

Matèries

Morbiditat, Persones grans, Interaccions dels medicaments, Catalunya

Matèries (anglès)

Morbidity, Older people, Drug interactions, Catalonia

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

TRONCOSO MARIÑO, Amelia, ROSO LLORACH, Albert, LÓPEZ JIMÉNEZ, Tomás, VILLEN, Noemí, AMADO GUIRADO, Ester, FERNÁNDEZ BERTOLIN, Sergio, CARRASCO RIBELLES, Lucía a., BORRÀS ANDRÉS, Josep maria, VIOLÁN, Concepción. Medication-Related Problems in Older People with Multimorbidity in Catalonia: A Real-World Data Study with 5 Years’ Follow-Up. _Journal of Clinical Medicine_. 2021. Vol. 10, núm. 4. [consulta: 20 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/176033]

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