Miniatura

Fitxers

franca2017_2705.pdf (1.03 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2017-09-25

Llicència de publicació

cc by (c) França et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/116941

IgG antibodies to synthetic GPI are biomarkers of immune-status to both Plasmodium falciparum and Plasmodium vivax malaria in young children

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

http://dx.doi.org/10.1186/s12936-017-2042-2

Resum

BACKGROUND: Further reduction in malaria prevalence and its eventual elimination would be greatly facilitated by the development of biomarkers of exposure and/or acquired immunity to malaria, as well as the deployment of effective vaccines against Plasmodium falciparum and Plasmodium vivax. A better understanding of the acquisition of immunity in naturally-exposed populations is essential for the identification of antigens useful as biomarkers, as well as to inform rational vaccine development. METHODS: ELISA was used to measure total IgG to a synthetic form of glycosylphosphatidylinositol from P. falciparum (PfGPI) in a cohort of 1-3 years old Papua New Guinea children with well-characterized individual differences in exposure to P. falciparum and P. vivax blood-stage infections. The relationship between IgG levels to PfGPI and measures of recent and past exposure to P. falciparum and P. vivax infections was investigated, as well as the association between antibody levels and prospective risk of clinical malaria over 16 months of follow-up. RESULTS: Total IgG levels to PfGPI were low in the young children tested. Antibody levels were higher in the presence of P. falciparum or P. vivax infections, but short-lived. High IgG levels were associated with higher risk of P. falciparum malaria (IRR 1.33-1.66, P = 0.008-0.027), suggesting that they are biomarkers of increased exposure to P. falciparum infections. Given the cross-reactive nature of antibodies to PfGPI, high IgG levels were also associated with reduced risk of P. vivax malaria (IRR 0.65-0.67, P = 0.039-0.044), indicating that these antibodies are also markers of acquired immunity to P. vivax. CONCLUSIONS: This study highlights that in young children, IgG to PfGPI might be a useful marker of immune-status to both P. falciparum and P. vivax infections, and potentially useful to help malaria control programs to identify populations at-risk. Further functional studies are necessary to confirm the potential of PfGPI as a target for vaccine development.

Matèries

Plasmodium falciparum, Plasmodium vivax

Matèries (anglès)

Plasmodium falciparum, Plasmodium vivax

Citació

Col·leccions

Articles publicats en revistes (ISGlobal)

Citació

FRANÇA, Camila t., LI WAI SUEN, Connie s. n., CARMAGNAC, Amandine, LIN, Enmoore, KINIBORO, Benson, SIBA, Peter, SCHOFIELD, Louis, MUELLER, Ivo. IgG antibodies to synthetic GPI are biomarkers of immune-status
                to both Plasmodium falciparum and Plasmodium vivax malaria in
                young children. _Malaria Journal_. 2017. Vol. 16, núm. 1, pàgs. 386. [consulta: 23 de gener de 2026]. ISSN: 1475-2875. [Disponible a: https://hdl.handle.net/2445/116941]

Exportar metadades

JSON - METS

Compartir registre