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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/201442
Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)
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Cases were patients with complicated urinary tract infection (cUTI), complicated intraabdominal (cIAI), pneumonia or bacteraemia from other sources (BSI-OS) due to CRE; control groups were patients with infection caused by carbapenem-susceptible Enterobacterales (CSE), and by non-infected patients, respectively. Matching criteria included type of infection for CSE group, ward and duration of hospital admission. Conditional logistic regression was used to identify risk factors. Findings Overall, 235 CRE case patients, 235 CSE controls and 705 non-infected controls were included. The CRE infections were cUTI (133, 56.7%), pneumonia (44, 18.7%), cIAI and BSI-OS (29, 12.3% each). Carbapenemase genes were found in 228 isolates: OXA-48/like, 112 (47.6%), KPC, 84 (35.7%), and metallo-beta-lactamases, 44 (18.7%); 13 produced two. The risk factors for CRE infection in both type of controls were (adjusted OR for CSE controls; 95% CI; p value) previous colonisation/infection by CRE (6.94; 2.74-15.53; <0.001), urinary catheter (1.78; 1.03-3.07; 0.038) and exposure to broad spectrum antibiotics, as categorical (2.20; 1.25-3.88; 0.006) and time-dependent (1.04 per day; 1.00-1.07; 0.014); chronic renal failure (2.81; 1.40-5.64; 0.004) and admission from home (0.44; 0.23-0.85; 0.014) were significant only for CSE controls. Subgroup analyses provided similar results. Interpretation The main risk factors for CRE infections in hospitals with high incidence included previous coloni-zation, urinary catheter and exposure to broad spectrum antibiotics.
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PÉREZ GALERA, Salvador, BRAVO FERRER, Jose m., PANIAGUA, María, KOSTYANEV, Tomislav, KRAKER, Marlieke e.a. de, FEIFEL, Jan, SOJO DORADO, Jesús, SCHOTSMAN, Joost, CANTÓN, Rafael, DAIKOS, George l., CAREVIC, Biljana, SPYRIDIS, Nikolaos, DORNEANU, Olivia, MICHOS, Athanasios, ROSA, Francesco giuseppe de, MASANOVIC, Mileva, CAVALLO, Rossana, PETROSILLO, Nicola, DICARO, Antonio, LANDINI, Maria paola, MATKOVIC, Dusan, LUPSE, Mihaela, TSIODRAS, Sotirios, KAPISYZI, Perlat, BLASI, Francesco, PASQUALE, Marta di, VISCOLI, Claudio, VATA, Andrei, VINCE, Adriana, KURTI, Arsim, TSIGOU, Evdoxia, MALTEZOS, Efstratios, DRAGOVAC, Gorana, KOMNOS, Apostolos, GOGOS, Charalampos, FRANZETTI, Fabio, ANTONELLI, Massimo, CORNECI, Dan, TOMESCU, Dana, DÍAZ POLLÁN, Beatriz, GEORGESCU, Anca, BUKARICA, Ljiljana, MITROVIĆ, Goran, KRSTIĆ, Nataša lukić, ORIGÜEN SABATER, Julia, CANO YUSTE, Ángela, MUÑOZ, Patricia, TAN, Lionel k., AZAP, Alpay, SANCAK, Banu, SAHIN, Arife, AKALIN, Halis, RAKA, Lul, BONTEN, Marc j., HRISTEA, Adriana, VIALE, Pierluigi, ROILIDES, Emmanuel, AKOVA, Murat, REGUERA, Jose maría, VALIENTE DE SANTIS, Lucía, TORRE CISNEROS, Julián, RADULOVIC, Lili, KIRAKLI, Cenk, GUTIÉRREZ GUTIÉRREZ, Belén, SHAW, Evelyn, FALAGAS, Matthew e., PINTADO, Vicente, GOOSSENS, Herman, RODRÍGUEZ BAÑO, Jesús, PÉREZ CAMACHO, Inés, SERNA, Almudena de la, MONTEAU, Sophie, PALOMO, Virginia, SORIANO, Elena, GUTIÉRREZ, David, MORENO, Elisa, PALACIOS BAENA, Zaira r., CHORAFA, Elsa, MORALES, Isabel, MALDONADO, Natalia, FRUTOS ADAME, Azahara, PLATA, Antonio, RUIZ MESA, Juan diego, SOBRINO DÍAZ, Beatriz, MÁRQUEZ GÓMEZ, Ignacio, GUZMÁN PUCHE, Julia, GRACIA AHUFINGER, Irene, RADOVANOVIC, Ivana, PÉREZ NADALES, Elena, TORRE GIMÉNEZ, Julián, PYRPASOPOULOU, Athina, IOSIFIDIS, Elias, PETROVIC, Sladjana, MARGARITA, Kyriakidou, CVETKOVI, Slavica, MELENTIJEVIC, Srdjan-sanja, BICMEN, Can, SENOL, Gunes, TUBAU, Fe, CÁMARA, Jordi, GUMUCIO, Victor daniel, TALAPAN, Daniela, BASSOULIS, Dimitris, DELIOLANIS, John, GIJÓN CORDERO, Desirée, PITIRIGA, Vassiliki ch., TRIARIDES, Nikolaos, ARGITI, Efstathia, LEGAKIS, Nikolaos j., RUIZ GARBAJOSA, Patricia, BARTOLONI, Alessandro, MEDIĆ, Deana, ROSSOLINI, Gian maria, FLORESCU, Simin-aysel, NICA, Maria, BENEA, Serban, PRIJIĆ, Sanja maričić, CIOFI DEGLI ATTI, Marta luisa, CANTERO CABALLERO, Mireia, PARRA RAMÍREZ, Lina m., KORTEN, Volkan, BILGIN, Hüseyin, DALEKOS, George n., STEFOS, Aggelos. Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA). _eClinicalMedicine_. 2023. Vol. 57. [consulta: 15 de gener de 2026]. ISSN: 2589-5370. [Disponible a: https://hdl.handle.net/2445/201442]